DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and Kif18b

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_932063.2	Gene:	Kif18b / 70218	MGIID:	2446979	Length:	834	Species:	Mus musculus

Alignment Length:	914	Identity:	297/914 - (32%)
Similarity:	415/914 - (45%)	Gaps:	231/914 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAK-QPYRDITKRMNKKLTM 72
            ::|.|||||...:|||.::|.:|:|:|...|:|||:|.|..  |.|.| ....:..|:..|.||.
Mouse    10 VRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGG--FPGLKWSGSHNGPKKKGKDLTF 72

  Fly    73 EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQD 137
            .|||||....:.:|:|:..|..::|:.|.|||||||.|||||||||.||||.|..||:.|||..:
Mouse    73 VFDRVFGEMATQEDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGREGEPGIMYLTTME 137

  Fly   138 LFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLRED-NNGVVVSGLCLTPIYSAEELL 201
            |:.:::|:.:.::|:|.:||||||||.:.:||...|||.:||| :.||||.||......|||:||
Mouse   138 LYRRLEARQEEKQFEVLISYLEVYNEQIHDLLEPKGPLTIREDPDKGVVVPGLSFHQPASAEQLL 202

  Fly   202 RMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITER---KTDTKRTVKLSMIDLAGSERAASTK 263
            .||..||..||||||||||.|||||||||:.::..:|   .|...|..|:|:|||||||||:||.
Mouse   203 EMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVAKMSLIDLAGSERASSTH 267

  Fly   264 GIGVRFKEGASINKSLLALGNCINKLAD--GLK-HIPYRDSNLTRILKDSLGGNCRTLMVANVSM 325
            ..|.|.:|||:||:|||||.|.:|.|||  |.| |:|||||.|||:||||:||||||:|:|.:|.
Mouse   268 AKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRLLKDSIGGNCRTVMIAAISP 332

  Fly   326 SSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKAT 390
            |||||||||||||||.|||:||.|||.||:........|.....::.||...|:|:.:..||.|.
Mouse   333 SSLTYEDTYNTLKYADRAKEIRLTLKSNVISVDHHISQYATICQQLQAEVAFLREKLQMYEAGAQ 397

  Fly   391 QLER--------------AGNSGFDP--------LELKTWYSKIDAVYAAARQLQEHVLGMRSKI 433
            .|::              ..:|...|        ||          .:|....|||..||..::.
Mouse   398 ALQQQCSPQPPTLSIPQSLSSSSLQPGPSSQSSTLE----------CHAKNETLQEESLGSDAQG 452

  Fly   434 KNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEE-------LPSWLSK 491
            :.|         :||    ...:|..|.:|            .|....|.|       .||..:|
Mouse   453 QEI---------VEE----SASEQEQCPQD------------KQCPTQKPEPNLPGSPSPSVQAK 492

  Fly   492 MEIAYQDLESLKREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSF 556
            ........:....:.:|..|.|:|
Mouse   493 PGTGQHSPQKQDADHSKQLALQVL----------------------------------------- 516

  Fly   557 RTACEVLNQTYDRLEDGQKLTPEIEAVFERLLRKM------RFADSEANTKMAEMNPLAVPVALR 615
                .:..:.|..|:....|||::.:.||.|.:.:      ..|:|..:..:|..:|||..:...
Mouse   517 ----RLAQRQYSLLQAANLLTPDMISEFETLQQLVLEESVDHRAESPRSPALARGDPLAQALCSE 577

  Fly   616 SSAQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPR------- 673
            |.:.....|.          .|..|:..:.|..::....:.|..||     :||::|.
Mouse   578 SKSSGYCGPV----------TRTMAKQLNGLTHTLGAPLAPDCTSD-----KTFQKPTKEKKRKL 627

  Fly   674 -----------NL---NETQVLGPCSSSSS---------------SSTSSSSSARKALTATVTKP 709
                       ||   .:.|...||....|               ...||.|.:.:...|||.|.
Mouse   628 TPEEPGSLPAPNLEMKRQRQSFLPCLRRGSLPKAQPCSEPRTPKRERASSPSPSSRVCPATVIKS 692

  Fly   710 R------------TVQQRLVSDLISDQNVRGGN------------EKIKKALLKSNH-------- 742
            |            |.......||.:..||...:            ||:...|..::.
Mouse   693 RVPLGPSALQNCSTPLALPTRDLNTTFNVSEESPSKPSFQEFVDWEKVSPELNSTDQPFLPSAPV 757

  Fly   743 --FTAQGLQRTLAAASLAKENVKYNANYVRKSPRALMAKALAGTSTLARKPLGSASK-------- 797
              || :|.:.:|.|.:.:|:         |::.|..:::   |.|.:||....:..|
Mouse   758 FIFT-KGRKPSLPAVTASKK---------RRTMRPSVSR---GRSCIARLHSSTLKKPNRPFTVP 809

  Fly   798 EPPL 801
            ||||
Mouse   810 EPPL 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	196/351 (56%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	191/344 (56%)
Kif18b	NP_932063.2	KISc_KIP3_like	18..353	CDD:276821	186/336 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..508		22/142 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..642		8/44 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	619..627		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..686		4/30 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..834		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	347	1.000	Domainoid score	I1037
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310221at33208
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		otm42756
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.810