Protein Alignment Klp67A and Kif19b

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_006249035.1
• Gene: Kif19b / 679924
• RGDID: 1598146
• Length: 976
• Species: Rattus norvegicus
• Alignment Length: 844
• Identity: 241/844 - (28%)
• Similarity: 373/844 - (44%)
• Gaps: 199/844 - (23%)

  Fly     1 MPSEQHTN-------------------IKVAVRVRPYNVRELEQKQRSII-KVMDRSALLFDPDE 45
            |||:|.|:                   :.||:|:||.|..|||:....|. ||.|:..:|.||.|
  Rat     1 MPSQQTTDPSPARGSPTLREMEPKDQQLMVALRIRPLNSTELEEGATVIAHKVGDQVVVLMDPGE 65

  Fly    46 EDDEFFFQGAKQPYRDITKRMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVY 110
            :           |...:....:::.|..||.|||...|.:.::......||:.|::|||.:||.|
  Rat    66 D-----------PEDTLRAHRSRERTFIFDTVFDQQASQETVYRVTIQHLVEGVISGYNATVFAY 119

  Fly   111 GATGAGKTFTMLGSEAHPGLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLT-KSGP 174
            |.:|||||.||||.:|.||:...|:.|||..|:...|..::.|.:||||:|||.:.:||. .||.
  Rat   120 GPSGAGKTHTMLGMDAEPGIYLQTLTDLFQAIEETQDNMEYSVSMSYLEIYNEVIRDLLNPSSGF 184

  Fly   175 LKLREDNNG-VVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITER 238
            |:||||:.| :.::|:......:|:|::::|..||..|||.||..|..||||||:.||.:....|
  Rat   185 LELREDSRGSIQIAGITEVSTSNAQEIMQLLTKGNRQRTQEPTATNKTSSRSHAVLQVTVHQRSR 249

  Fly   239 KTDTKRTVKLS---MIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLAD----GLKHI 296
            ..|....|:|.   |:|||||||||.|:..|.|.||||.||:||||||||||.|::    ..:::
  Rat   250 GGDLAEEVRLGRLFMVDLAGSERAAQTQNRGKRMKEGAHINRSLLALGNCINALSEKGGSRAQYV 314

  Fly   297 PYRDSNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPT 361
            .:|||.|||:|||:||||.||:|:|::|.:|.::|::..||.||.|||.|:|.:|:|:|......
  Rat   315 NFRDSKLTRLLKDALGGNSRTVMIAHISPASTSFEESRTTLLYAYRAKNIKTRVKRNLLNVSYRI 379

  Fly   362 EFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHV 426
            ..|...|.::..|.|.||                              |||:      :|.:|
  Rat   380 AQYTDVISDLRREIEHLK------------------------------SKIE------KQDKE-- 406

  Fly   427 LGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSK 491
              .:|....::.:.|:.::.||       |.|:.....|  |..:.....|||
  Rat   407 --KKSDPSVLDIQVTVPQDAEE-------DSRLQMNKIR--AQLIGAFKEQME------------ 448

  Fly   492 MEIAYQDLESLKREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSF 556
            |..:..:||:...|::...:..:|.:    .|.|..|       :|.         |:|..:|.
  Rat   449 MRRSLVELENTNIELHIDMSRHLLTI----ADWEKTL-------HHA---------NMDKSKKD- 492

  Fly   557 RTACEVLNQTYDRLEDGQKL----TPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSS 617
                   .:..|  .||:::    .||:           ..|..|.|..:|
  Rat   493 -------KEPVD--ADGEEVEASEPPEV-----------ALAREEVNLLLA-------------- 523

  Fly   618 AQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLG 682
               |::.|.:|.|..::|...|.|....:...:   ..|.|..|..|:.:...|...|
  Rat   524 ---EQQKTAALKAGLEQRLAHAKQKASQMEKLL---PRQVTSEDQREVLQLLCRAHEL------- 575

  Fly   683 PCSSSSSSSTSSSSSARKALTATVTKPRTVQQRLVSDLISDQNVRGGNEKIK-KAL--------- 737
               ...::...:.:..||.|..  .|...:|:.....|:.::.::|..:.:: |.|
  Rat   576 ---EVENTELQADNLCRKNLLC--QKDFVIQRYHQHRLLCEEVIQGQRQLMQDKGLSVPEPLEQQ 635

  Fly   738 --LKSNHFTAQGLQRTLAAASLAKENVKYNANYVRKSPRALMAKALAGTSTLARKPLGSASKEP 799
              |.|.......|.|.|...|:...::: :...:..||        |.|...:.:|||.....|
  Rat   636 YRLYSRELGEGTLDRLLLQLSVMSSSLQ-DGPIMNVSP--------APTEETSGEPLGDRRDLP 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	152/366 (42%)
Kif19b	XP_006249035.1	KISc_KIP3_like	27..364	CDD:276821	152/347 (44%)
		SMC_prok_B	<386..>620	CDD:274008	62/367 (17%)