DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and kif19

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_005156460.1	Gene:	kif19 / 565913	ZFINID:	ZDB-GENE-080215-2	Length:	1015	Species:	Danio rerio

Alignment Length:	890	Identity:	259/890 - (29%)
Similarity:	404/890 - (45%)	Gaps:	183/890 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVAVRVRPYNVRELEQKQRSII-KVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTM 72
            :.||:|:||.:..|||:....|. ||.|:..:|.||.|:.|:.           :....:::.|.
Zfish    12 LTVALRIRPLSDAELEEGATIIAHKVDDQMVVLLDPMEDPDDI-----------LRAHRSREKTY 65

  Fly    73 EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQD 137
            .||..||...:..:::...|..|::.:::|||.:||.||.||.|||:||||::..||:...|:.|
Zfish    66 MFDVAFDYSATQDEVYRYTTKGLIEGLISGYNATVFAYGPTGCGKTYTMLGTDREPGIYVRTLND 130

  Fly   138 LFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLT-KSGPLKLREDNNG-VVVSGLCLTPIYSAEEL 200
            ||..|:..||..::.|.:||||:|||.:.:||. .||.|.||||:.| :.|:|:......:|.|:
Zfish   131 LFKAIEETSDDMQYSVSMSYLEIYNEMIRDLLNPSSGFLDLREDSKGEIQVAGITEVSTINAREI 195

  Fly   201 LRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTV---KLSMIDLAGSERAAST 262
            :.:||.||..|||.||.||..||||||:.||.:|...|..|..:.|   :|.||||||||||:.|
Zfish   196 MELLMKGNKQRTQEPTAANQTSSRSHAVLQVVVRQQSRCRDILQEVRFARLFMIDLAGSERASQT 260

  Fly   263 KGIGVRFKEGASINKSLLALGNCINKLAD--GLKHIPYRDSNLTRILKDSLGGNCRTLMVANVSM 325
            :..|.|.||||.||:||||||||||.|::  |.|::.||||.|||:||||||||.||:|:|::|.
Zfish   261 QNRGQRLKEGAHINRSLLALGNCINALSEKNGNKYVNYRDSKLTRLLKDSLGGNSRTVMIAHISP 325

  Fly   326 SSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKAT 390
            :||.:||:.|||.||.|||.|||.:|:|:|........|...|.::.:|.:|||::      .|.
Zfish   326 ASLAFEDSRNTLTYADRAKSIRTRVKRNLLNVSYHIAQYTSIISDLRSEIQRLKKK------IAD 384

  Fly   391 QLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQTLKKELEEFRKLMCV 455
            |..|..|.  |..::              |.:|..|....|:.......|..::.::.||:.|.:
Zfish   385 QASRQINP--DRTDI--------------RHVQAEVQAHSSQQSRAEMDQLREQLIDAFRQQMDI 433

  Fly   456 DQRVC------------------------QEDFRRFANYM------------------------- 471
            .:|:.                        ||.|||...:.
Zfish   434 RKRLMELDNSNMEIQIDTSKHLLTIADWEQERFRRRKKWQGERRKESFNKDESEKDSDSPESLPD 498

  Fly   472 STLTSQ-----------------MEKYKEELPSWLSKMEIAYQDLES-LKREVNKSKAYQILIVY 518
            ||.|.:                 ::|.|..|...|:::....:.||. |.|.|:..:..::|.:.
Zfish   499 STETQEVAIARENLVTLMAEQKKIQKQKAGLEQRLAELREKARRLEELLPRRVSSEEQREVLCLL 563

  Fly   519 VKYKDLELQ--------LTKQNIFNNHVNAINQELVENLDLMRKSFRTAC-EVLNQTYDRLEDGQ 574
            .|..:||::        |.|.|:.... |.:.|...::        |..| |::.|....::|..
Zfish   564 CKVHELEIENAEMQSSALLKDNVIRQK-NVVVQRFEQH--------RHLCHEIIQQQRQFIDDHS 619

  Fly   575 KLT-PEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKRQ-R 637
            .|. |.::.::|..:::|   |.:...::..::...:    |:.....|.....:|..::.|. .
Zfish   620 LLVPPHLQELYEMYMKEM---DEKNLDRVVALDKFTI----RTLKVHHEGSLPKITLPSRGRDPL 677

  Fly   638 QAAQSDDDLHLSMEDFDSQD-------------TESDSEELHRTFKRP-RNLNETQVLGP----- 683
            |...||.:...::...:.|.             .|.|.|   |.||.. :.:..|.|:.|
Zfish   678 QELDSDQESVRTLASDNRQGRTKLRRHTLPPILPEPDGE---RVFKSSHKQMKNTVVMTPPPIHI 739

  Fly   684 ------------------CSSSSSSSTSSSSSARKALTATVTKPRTVQQRLVSDLISDQNVRG-G 729
                              ||..|.|.:|...|:.::.......|.|.::|       .|.:|| .
Zfish   740 NGQGNRELLPSVLDEALRCSHLSHSMSSHLDSSPESSENGTDAPLTPKER-------QQILRGVQ 797

  Fly   730 NEKIKKALLKSNHFTAQGLQRTLAAASLAKENVKYNANYVRKSPR 774
            |..:|.|..:|.......|:.....:.|..:..|.|.:.....|:
Zfish   798 NIAVKAARRRSKVLEIDALRLPPPPSPLDPKKHKSNLSLSEAPPK 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	163/351 (46%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	159/344 (46%)
kif19	XP_005156460.1	KISc	11..353	CDD:214526	163/351 (46%)
kif19	XP_005156460.1	KISc_KIP3_like	11..346	CDD:276821	159/344 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740