DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and kif18a

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001016245.2	Gene:	kif18a / 548999	XenbaseID:	XB-GENE-990470	Length:	947	Species:	Xenopus tropicalis

Alignment Length:	953	Identity:	305/953 - (32%)
Similarity:	466/953 - (48%)	Gaps:	182/953 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLT 71
            ::::|.|||||.|.:|.:.....:::|:|...|:|||..| :..||.|.....||||||.||.|.
Frog    10 SHVRVVVRVRPENEKEKQGNFSRVVQVVDNHILVFDPKVE-EVGFFHGRSAANRDITKRKNKDLK 73

  Fly    72 MEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQ 136
            ..||.|||..::..::||:.|..:::.|||||||:|..|||||||||.|||||...||:.||||.
Frog    74 FVFDCVFDDSSTQLEVFEQTTKIVLEGVLNGYNCTVLAYGATGAGKTHTMLGSPGEPGVMYLTMM 138

  Fly   137 DLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLRED-NNGVVVSGLCLTPIYSAEEL 200
            :|:::|::..|.:..:|.:||||||.|.:.:||:.||.|.:||| ..||||.||.|....||||:
Frog   139 ELYNRIESVKDEKVCNVAISYLEVYIEQIRDLLSNSGALAVREDAQKGVVVQGLTLHQPKSAEEI 203

  Fly   201 LRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTV---KLSMIDLAGSERAAST 262
            |:||..||.:|||||||.||.||||||:||:::|..::.....:.|   |:.:|||||||||::|
Frog   204 LQMLDYGNKNRTQHPTDMNASSSRSHAVFQIYLRQQDKTASINQNVRIAKMCLIDLAGSERASAT 268

  Fly   263 KGIGVRFKEGASINKSLLALGNCINKLAD---GLKHIPYRDSNLTRILKDSLGGNCRTLMVANVS 324
            ...|.|.:||.:||:|||||||.||.|||   ..:|||||:|.|||:|||||||||||:|:|.||
Frog   269 NAKGERLREGTNINRSLLALGNVINALADPKSKKQHIPYRNSKLTRLLKDSLGGNCRTIMIAAVS 333

  Fly   325 MSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALE-AK 388
            .|||:|:|||||||||:|||.|::.:|.||:........|||..::...|...|||:.||.| .|
Frog   334 PSSLSYDDTYNTLKYANRAKDIKSAVKSNVVSLDSHISQYVKICEQQKKEIAALKEKLKAYEDQK 398

  Fly   389 ATQLERAGNSGFDP-----LELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQTLKKELEE 448
            |....:...:...|     .|:|.:...:..::....:::...|.:..:.|....:...:|:..|
Frog   399 AIAPGKPKQNVLLPPCQNQAEIKRFQEILRCLFTNREEIRAEYLNLEMRFKENELKTYYQKQCFE 463

  Fly   449 FRKLMCVDQRV----CQEDFRRFANYMSTLTSQ---MEKYK-------EELPSWLSKMEIAYQDL 499
            ..:::|..::.    |:.|.|     :..|.:|   ::|.|       ||..:||.::|...:.|
Frog   464 QIQMLCSQEKAVKASCKRDHR-----VEVLKNQNVLLQKKKEDELKRLEENTTWLHRLESEMKLL 523

  Fly   500 ES---LKREVNKSKAYQILIVYVKYKDLELQ---LTKQNIFNNHVNAINQELVEN-LDLMRKSFR 557
            .:   :..|:.|......|.:.|  .||:.|   :|:........|..|::||.. |..:|:.:.
Frog   524 NNDGKMPEELGKDLQCHHLTLEV--TDLKTQIKHMTRLVALQERENRYNEKLVNALLPSLRRQYL 586

  Fly   558 TACEV-LNQTYDRLEDGQKLTPEIEAVF---ERLLRKMR---FAD----SEAN------------ 599
            ...:| |..|.            :||.|   |:|:::.:   :||    .|||
Frog   587 LLSQVGLADTC------------VEADFKKIEQLVQREKAVVWADQAESDEANKCDDSEIAAVVT 639

  Fly   600 ------------------------TKMAEM-NPLAV----PVALRSSAQE--EEEPTCSL-TASA 632
                                    .|||:. ||||:    ..|..|..:|  |..|..:: ....
Frog   640 FPHLKYSQTTPCKEEKCAQLIQSAEKMAQKENPLAIVRHFTGAQNSQTEEFKENVPQKAINVVPP 704

  Fly   633 KKRQRQAAQSDDDLHLSMEDFDSQDTESDSEEL-------------------------------- 665
            :||.|:...   |..:|.|  ..|..:|.|:||
Frog   705 RKRTRRKLM---DSPMSTE--SHQQNDSISDELSPIVYTPETSNNTVTLLKQVAKIPCVVGKREN 764

  Fly   666 ---------HRTFKRP-------RNLNETQVL----GPCSSSSSSSTSSSSSA---RKALTATVT 707
                     |..|..|       .::|.|.:|    |..||.:::...|.:::   |..|::.::
Frog   765 NPGLPDYAGHAGFSFPMTSESKDTDMNSTVILSHGDGDKSSENTADAKSGTTSMLQRLGLSSLLS 829

  Fly   708 KPRTVQQRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQRTLAAASLAKENVKYNANYVRKS 772
            ||   ..:.:|:..|...:....|:.:|.|..:.:...:.....|..|...::::..:...:|
Frog   830 KP---SSKPLSEKPSYMAMTSAAERKRKLLSLAGNSAVKEDSVALPTAKRVRQDISLDCKALR-- 889

  Fly   773 PRALMAKALAGTS----TLARKPLGSASKEPPLVKFNRAASFR 811
                :.:..|||:    ..||:.|..:..|..|....:..||:
Frog   890 ----VQRVAAGTTRNKDNCARRRLPKSVSESALGVKGKPFSFQ 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	188/351 (54%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	186/344 (54%)
kif18a	NP_001016245.2	Kinesin	20..355	CDD:278646	181/335 (54%)
kif18a	NP_001016245.2	KISc_KIP3_like	20..355	CDD:276821	181/335 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I1009
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1977
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310221at33208
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		otm47861
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100