DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and Klp98A

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	233/940 - (24%)
Similarity:	377/940 - (40%)	Gaps:	262/940 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLT 71
            :::||||||||:|.||::...:.|:::.::...|..|           ..|..||..:..:...|
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKP-----------RLQSIRDAGRDNHHDFT 55

  Fly    72 MEFDR-VFDIDN----SNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLT 131
            .::.. .||.::    :.:.::.:....:||....|||..||.||.||:||||||:|:..:|||.
  Fly    56 FDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLI 120

  Fly   132 YLTMQDLFDKIQ-AQSDVRKFDVGVSYLEVYNEHVMNLLTKSGP---LKLREDNN-GVVVSGLCL 191
            ....::||.::: .|.....:....||||:|||.|.:||.....   |::||..: |..|..|..
  Fly   121 PRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQ 185

  Fly   192 TPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQV----HIRITERKTDTKRTVKLSMID 252
            ..:...:|:...:..||:.||...|:.|..||||||||.:    .:.:.:..::|  ..|:.::|
  Fly   186 HAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSET--VSKIHLVD 248

  Fly   253 LAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLAD----------------------GLKH 295
            |||||||.:|...|.|.||||.|||||:.||:.|:.||:                      .:.:
  Fly   249 LAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLY 313

  Fly   296 IPYRDSNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKI--RTTLKQ------ 352
            ||||||.||.:||||||||.:|:|:|.:|.:...|.:|.:||:||:|||.|  :.|:.:
  Fly   314 IPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKL 378

  Fly   353 --------NVLKSKMPTEFY-VKKIDEVVAENERLKERNKAL----------------EAKATQL 392
                    |.|||.:..:.: ::...:|:|:.::.:.:.|.|                |.|:..|
  Fly   379 IRELREEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGL 443

  Fly   393 ERAG-------------------NSGFDPLELKTWYSKIDAVYAAARQ----------------- 421
            .::|                   .:|.....||...::|.:..|...|
  Fly   444 RKSGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIF 508

  Fly   422 -----------------LQEHVLGMRSKIK----------NINYRQTLKKELEEFRKLMCVDQRV 459
                             :..|::....:|.          || :|.....|..:.||    |...
  Fly   509 LKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNI-FRFNNPAEAAKLRK----DLSR 568

  Fly   460 CQEDFRRFANYMSTLTSQMEKY-------KEELPSWLSKMEIAYQDLESLKREVNKSKAYQILIV 517
            .|.|..|    :|.:||..|..       .|:..|...:.|..|.....:.|:
  Fly   569 SQLDMSR----LSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRD------------ 617

  Fly   518 YVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLE----DGQKL-- 576
                 |.|||...:.|.:...||:.|..||.:. |...::|....|.:...|||    ||.:|
  Fly   618 -----DPELQDENRKILDTIENALKQLNVERVQ-MHDQYKTKVRKLTEELIRLEQEEMDGLQLLN 676

  Fly   577 --TPEIEAVFERLL--------------------------RKMRFAD---------------SEA 598
              ..|:.|..:.||                          :|..|::               .|.
  Fly   677 CREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEM 741

  Fly   599 NTKMAEMNPLAVPVALRSS-------AQEEEEPTCSLTASAKKRQRQAAQSDDDLHLS------- 649
            ..|:.|..||...:.|:.|       ||..::.........:|...|.|:.:..|:.|
  Fly   742 GMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKV 806

  Fly   650 ---MEDFDSQ---------DTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSSTSSSSSARKAL 702
               |.:..:|         ::|::|:.:     |.:..|....||..|.|:|:||:.:....|:.
  Fly   807 DETMLEIQAQLERLRLERAESEAESQAM-----RAKKQNMKLQLGNKSMSTSTSTNEADDVSKSD 866

  Fly   703 T-ATVTKPRTVQQRLVSDLISDQNVRGGNE 731
            | .|.....|.|..|  .|:|...:..|.:
  Fly   867 TYETCDTFHTAQSNL--SLVSSPTITEGQQ 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	133/396 (34%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	131/373 (35%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	133/381 (35%)
		KISc	3..371	CDD:214526	133/380 (35%)
		Kinesin_assoc	370..478	CDD:292801	15/107 (14%)
		FHA	456..555	CDD:238017	11/99 (11%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940