DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and kif22

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_031748433.1	Gene:	kif22 / 394855	XenbaseID:	XB-GENE-979888	Length:	680	Species:	Xenopus tropicalis

Alignment Length:	794	Identity:	190/794 - (23%)
Similarity:	323/794 - (40%)	Gaps:	198/794 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EQH-----TNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDIT 63
            :||     ..::||||:|||..:|.|:...:.::.:|..:|                     :|.
Frog    22 DQHKKPSSARVRVAVRLRPYMEKEDEKAPAACVRGLDSQSL---------------------EIV 65

  Fly    64 KRMNKKLTM--EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEA 126
            ...|:..||  :||..:....:.::::......::..:|.|.|.|||.||.||||||.||||:.:
Frog    66 NWRNQLETMQYQFDAFYGDSATQREIYMGSVCHILPHLLIGQNASVFAYGPTGAGKTHTMLGNPS 130

  Fly   127 HPGLTYLTMQDLFDKIQA-----QSDVRKFDVGVSYLEVYNEHVMNLL-TKSGPLKLRED-NNGV 184
            .||:....::||....:.     :::...:.:.:||:|:|.|.||:|| .|:..|.:||| ::.:
Frog   131 QPGVIPRAVRDLLQMTRTAAGGHENENWTYTITMSYVEIYQEKVMDLLEPKNKDLPIREDKDHNI 195

  Fly   185 VVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKR-TVKL 248
            ::.|:....|.|..:.....:..:.:||...|..|..||||||:..:.::.:::.:..:: |.||
Frog   196 LIPGVTQKTINSFGDFDEHFIPASQNRTVASTKLNDRSSRSHAVLLIKVQKSQQVSPFRQLTGKL 260

  Fly   249 SMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSLGG 313
            .:|||||||....|...|:|.||..:||.||..|...::.|..||..||||||.|||:|:|||||
Frog   261 YLIDLAGSEDNRRTGNQGIRLKESGAINSSLFTLSKVVDALNQGLPRIPYRDSKLTRLLQDSLGG 325

  Fly   314 NCRTLMVANVSMSSLTYEDTYNTLKYASRAKKI-------RTTLKQNVLKS-KMPTEFYVKKIDE 370
            ...::|:||::.....|.||...|.:|:::|:|       .||.....|.: |.|.|    :.:.
Frog   326 TAHSVMIANIAPEQKYYFDTLTALNFAAKSKQIINKPFSQETTQSIAALPAMKRPRE----EAET 386

  Fly   371 VVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKN 435
            .....:|.|       :|....|.:.|:..|               ||::             :.
Frog   387 AAGSRQRKK-------SKTDSTESSPNTSMD---------------AASK-------------RK 416

  Fly   436 INYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLE 500
            :|........:|...||    .::..|...:.|..:||       .|.|..:.|.|.|.:..::|
Frog   417 LNLAALDPAVVERLLKL----DKILTEKGMKEAQLLST-------PKRERMALLKKWEESQMEIE 470

  Fly   501 SLKREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQ 565
            .||.               |.|:||                 |:.:|....:.||..:.|.:.:.
Frog   471 RLKE---------------KQKELE-----------------QKAIEAEARLEKSTNSDCNLSDS 503

  Fly   566 TYDRLEDGQKLTPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTA 630
            :..            |..|...||       ..||..|:...:     ||....:.|.|..:...
Frog   504 SVS------------ECTFRAPLR-------GRNTSTAKAKKV-----LRVLPMQGEHPGANGGV 544

  Fly   631 SAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSS---- 691
            .|.:|           |:..|. :..:|...:.:|..|.:....:.|.:...|.|.....:
Frog   545 LATER-----------HVDPES-ERSETLLGNSQLQSTIEEGIPVFEKKKKKPVSCDGRENQPTW 597

  Fly   692 -----TSSSSSARKAL-----TATVTKPRTVQQ-------------------RLVSDLISDQNVR 727
                 |....|.|:.:     |.:|.:.:::|:                   :.|.||.|   :.
Frog   598 EVNVRTDLLESGRERILKLLNTGSVKELKSLQKIGDKKAKLIIGWREVNGPFKNVEDLAS---LE 659

  Fly   728 GGNEKIKKALLKSN 741
            |.:.|...:.:|:|
Frog   660 GISAKQVTSFIKAN 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	116/361 (32%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	113/347 (33%)
kif22	XP_031748433.1	KISc_KID_like	31..356	CDD:276827	112/345 (32%)
kif22	XP_031748433.1	HHH_3	617..665	CDD:403900	8/50 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910