DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and kif18a

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_956533.1	Gene:	kif18a / 393209	ZFINID:	ZDB-GENE-040426-862	Length:	895	Species:	Danio rerio

Alignment Length:	803	Identity:	281/803 - (34%)
Similarity:	403/803 - (50%)	Gaps:	163/803 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLT 71
            :::||.|||||.|.:|.:...:.::.|:|...|:|||.|| :..||:|.:...||:.||.||.|.
Zfish     8 SHVKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEE-EVTFFRGQRVGNRDVRKRANKDLK 71

  Fly    72 MEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQ 136
            ..||.||..::|..::||..|..:||.|||||||:||.|||||||||.||||:...||:.:|||:
Zfish    72 FVFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPGVMFLTMK 136

  Fly   137 DLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLRED-NNGVVVSGLCLTPIYSAEEL 200
            :||.::....:.:.|:|..||||||||.:.:|||.||||.:||| :|||||.||.|....|||.:
Zfish   137 ELFARMDLIKEDKVFNVAFSYLEVYNEQIRDLLTNSGPLAVREDGSNGVVVQGLTLHQPKSAEHI 201

  Fly   201 LRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTK---RTVKLSMIDLAGSERAAST 262
            |..|..||.:|||||||.||.||||||:||:::|..::.....   |..|:|:|||||||||::|
Zfish   202 LEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPNVRVAKMSLIDLAGSERASAT 266

  Fly   263 KGIGVRFKEGASINKSLLALGNCINKLAD---GLKHIPYRDSNLTRILKDSLGGNCRTLMVANVS 324
            ...|.|.:|||:||:|||||||.||.||:   ...|||||||.|||:|||||||||||:|:||||
Zfish   267 NTKGARLREGANINRSLLALGNVINTLANPKCKKTHIPYRDSKLTRLLKDSLGGNCRTVMIANVS 331

  Fly   325 MSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKA 389
            .|||:||||:||||||:|||:|::||:.||:........|....::..||...||::.|..|.:
Zfish   332 PSSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIVMLKQKLKEYEER- 395

  Fly   390 TQLERAGNSGFDPL------ELKTWYSKIDAVYAAARQL-QEHVLGMRSKIKNINYRQTLKKELE 447
                :|.....:|:      |.:.....:.:|::...:| :||:              .::|:|.
Zfish   396 ----KAEAPALNPISIQKRAEFEKMSESLRSVFSDRLKLRKEHL--------------DIEKQLN 442

  Fly   448 EFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKSKAY 512
            |.|..|                          :::|   ||..:..|.:.|        ||::.
Zfish   443 ESRLTM--------------------------RHRE---SWHQQSLIFFPD--------NKAER- 469

  Fly   513 QILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTY-DRLEDGQKL 576
                ...||:      .|.....:|...:.|.|:|:    .|.|:.     |:.: .|:|:..||
Zfish   470 ----ATCKYE------RKLASLKSHQEHLQQRLMES----EKCFQE-----NEGWLHRIENEMKL 515

  Fly   577 ------TPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEE-----------P 624
                  ||| |...|....:::...|:....|..|:.|.       |.|::|.           .
Zfish   516 LGHDGHTPE-ELKKELQCHQLQLQISDLQQHMEHMSHLI-------SVQDQENTHTHKLVNALLS 572

  Fly   625 TCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNL----NETQVLGPCS 685
            ||       :||          ||:::...:....|:.|||.|...|.|.:    .|     ...
Zfish   573 TC-------RRQ----------HLALKAMSADGDGSEWEELERLVHRERAVVWADQE-----KAE 615

  Fly   686 SSSSSSTSSSSSARKALTATVTKPRTVQQRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQR 750
            .....|...|:..|..|:             .|.|:|.|:....:||..:.       |:|.|:.
Zfish   616 DKRDDSGIGSTHLRPILS-------------FSHLVSHQSTPCSSEKHTRR-------TSQRLRP 660

  Fly   751 TLAAASLAKENVKYNANYVRKSP 773
            |.::......:....|..|.|.|
Zfish   661 THSSKDCGPHHQVAEAEGVLKKP 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	195/351 (56%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	192/344 (56%)
kif18a	NP_956533.1	KISc	9..354	CDD:214526	192/345 (56%)
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	192/344 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587915
Domainoid	1	1.000	357	1.000	Domainoid score	I932
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	380	1.000	Inparanoid score	I2026
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310221at33208
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		oto41623
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790