Protein Alignment Klp67A and kif18a

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_956533.1
• Gene: kif18a / 393209
• ZFINID: ZDB-GENE-040426-862
• Length: 895
• Species: Danio rerio
• Alignment Length: 803
• Identity: 281/803 - (34%)
• Similarity: 403/803 - (50%)
• Gaps: 163/803 - (20%)

  Fly     7 TNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLT 71
            :::||.|||||.|.:|.:...:.::.|:|...|:|||.|| :..||:|.:...||:.||.||.|.
Zfish     8 SHVKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEE-EVTFFRGQRVGNRDVRKRANKDLK 71

  Fly    72 MEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQ 136
            ..||.||..::|..::||..|..:||.|||||||:||.|||||||||.||||:...||:.:|||:
Zfish    72 FVFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPGVMFLTMK 136

  Fly   137 DLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLRED-NNGVVVSGLCLTPIYSAEEL 200
            :||.::....:.:.|:|..||||||||.:.:|||.||||.:||| :|||||.||.|....|||.:
Zfish   137 ELFARMDLIKEDKVFNVAFSYLEVYNEQIRDLLTNSGPLAVREDGSNGVVVQGLTLHQPKSAEHI 201

  Fly   201 LRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTK---RTVKLSMIDLAGSERAAST 262
            |..|..||.:|||||||.||.||||||:||:::|..::.....   |..|:|:|||||||||::|
Zfish   202 LEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPNVRVAKMSLIDLAGSERASAT 266

  Fly   263 KGIGVRFKEGASINKSLLALGNCINKLAD---GLKHIPYRDSNLTRILKDSLGGNCRTLMVANVS 324
            ...|.|.:|||:||:|||||||.||.||:   ...|||||||.|||:|||||||||||:|:||||
Zfish   267 NTKGARLREGANINRSLLALGNVINTLANPKCKKTHIPYRDSKLTRLLKDSLGGNCRTVMIANVS 331

  Fly   325 MSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKA 389
            .|||:||||:||||||:|||:|::||:.||:........|....::..||...||::.|..|.:
Zfish   332 PSSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIVMLKQKLKEYEER- 395

  Fly   390 TQLERAGNSGFDPL------ELKTWYSKIDAVYAAARQL-QEHVLGMRSKIKNINYRQTLKKELE 447
                :|.....:|:      |.:.....:.:|::...:| :||:              .::|:|.
Zfish   396 ----KAEAPALNPISIQKRAEFEKMSESLRSVFSDRLKLRKEHL--------------DIEKQLN 442

  Fly   448 EFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKSKAY 512
            |.|..|                          :::|   ||..:..|.:.|        ||::.
Zfish   443 ESRLTM--------------------------RHRE---SWHQQSLIFFPD--------NKAER- 469

  Fly   513 QILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTY-DRLEDGQKL 576
                ...||:      .|.....:|...:.|.|:|:    .|.|:.     |:.: .|:|:..||
Zfish   470 ----ATCKYE------RKLASLKSHQEHLQQRLMES----EKCFQE-----NEGWLHRIENEMKL 515

  Fly   577 ------TPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEE-----------P 624
                  ||| |...|....:::...|:....|..|:.|.       |.|::|.           .
Zfish   516 LGHDGHTPE-ELKKELQCHQLQLQISDLQQHMEHMSHLI-------SVQDQENTHTHKLVNALLS 572

  Fly   625 TCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNL----NETQVLGPCS 685
            ||       :||          ||:::...:....|:.|||.|...|.|.:    .|     ...
Zfish   573 TC-------RRQ----------HLALKAMSADGDGSEWEELERLVHRERAVVWADQE-----KAE 615

  Fly   686 SSSSSSTSSSSSARKALTATVTKPRTVQQRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQR 750
            .....|...|:..|..|:             .|.|:|.|:....:||..:.       |:|.|:.
Zfish   616 DKRDDSGIGSTHLRPILS-------------FSHLVSHQSTPCSSEKHTRR-------TSQRLRP 660

  Fly   751 TLAAASLAKENVKYNANYVRKSP 773
            |.::......:....|..|.|.|
Zfish   661 THSSKDCGPHHQVAEAEGVLKKP 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	192/344 (56%)
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	192/344 (56%)
		SMC_N	<345..572	CDD:481474	63/310 (20%)