DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and KIF22

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_024306038.1	Gene:	KIF22 / 3835	HGNCID:	6391	Length:	723	Species:	Homo sapiens

Alignment Length:	718	Identity:	189/718 - (26%)
Similarity:	291/718 - (40%)	Gaps:	192/718 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTM- 72
            ::||||:||:               :|.:|...||.      ..:|......:|....|.:.|:
Human    44 VRVAVRLRPF---------------VDGTAGASDPP------CVRGMDSCSLEIANWRNHQETLK 87

  Fly    73 -EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQ 136
             :||..:...::.||::.....|::..:|.|.|.||..||.||||||.|||||...||:....:.
Human    88 YQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALM 152

  Fly   137 DLFDKIQ---AQSDVRKFDVGVSYLEVYNEHVMNLL-TKSGPLKLREDNNG-VVVSGLCLTPIYS 196
            ||....:   |:.......|.:||||:|.|.|::|| ..||.|.:|||..| :::.||...||.|
Human   153 DLLQLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLSQKPISS 217

  Fly   197 AEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTD-TKRTVKLSMIDLAGSERAA 260
            ..:..|..:..:.:||...|..|..||||||:..|.:...||... .:|..||.:|||||||...
Human   218 FADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNR 282

  Fly   261 STKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSLGGNCRTLMVANVSM 325
            .|...|:|.||..:||.||..||..::.|..||..:|||||.|||:|:|||||:..::::||::.
Human   283 RTGNKGLRLKESGAINTSLFVLGKVVDALNQGLPRVPYRDSKLTRLLQDSLGGSAHSILIANIAP 347

  Fly   326 SSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKAT 390
            ....|.||.:.|.:|:|:|::......|  :|..|     ..:..|....:.|....:|..|:..
Human   348 ERRFYLDTVSALNFAARSKEVINRPFTN--ESLQP-----HALGPVKLSQKELLGPPEAKRARGP 405

  Fly   391 QLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQTLKKELEEFRKLMCV 455
            :.|..|:.  :|:          |..|:|.|                       :|...:||..:
Human   406 EEEEIGSP--EPM----------AAPASASQ-----------------------KLSPLQKLSSM 435

  Fly   456 DQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKSKAYQILIVYVK 520
            |..:.:    |..:....|.||   ..:..|.           |.:.|||      ..:|:..|:
Human   436 DPAMLE----RLLSLDRLLASQ---GSQGAPL-----------LSTPKRE------RMVLMKTVE 476

  Fly   521 YKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKLTPEIEAVFE 585
            .||||:                                         :||:..||   |:||  :
Human   477 EKDLEI-----------------------------------------ERLKTKQK---ELEA--K 495

  Fly   586 RLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKR--------QRQAAQS 642
            .|.:|   |:.:.|.....:.||:             ..|.:.....||.        |.|||..
Human   496 MLAQK---AEEKENHCPTMLRPLS-------------HRTVTGAKPLKKAVVMPLQLIQEQAASP 544

  Fly   643 DDDLHL--------SMEDFDSQDTESDSEELHRTFKRP-------------------RNLNETQV 680
            :.::|:        .:|..|:.:.|..:|:.......|                   |:|...|.
Human   545 NAEIHILKNKGRKRKLESLDALEPEEKAEDCWELQISPELLAHGRQKILDLLNEGSARDLRSLQR 609

  Fly   681 LGP 683
            :||
Human   610 IGP 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	125/351 (36%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	125/344 (36%)
KIF22	XP_024306038.1	KISc_KID_like	43..366	CDD:276827	124/342 (36%)
KIF22	XP_024306038.1	ComEA	<596..632	CDD:333350	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810