Protein Alignment Klp67A and KIF11

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Alignment Length: 976
• Identity: 243/976 - (24%)
• Similarity: 398/976 - (40%)
• Gaps: 250/976 - (25%)

  Fly     4 EQHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNK 68
            |:..||:|.||.||:|:.|.:....||::.        ||..::......|       :..:.::
Human    14 EKGKNIQVVVRCRPFNLAERKASAHSIVEC--------DPVRKEVSVRTGG-------LADKSSR 63

  Fly    69 KLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGS--------- 124
            | |..||.||.......|::.....|::|.|:.||||::|.||.||.||||||.|.
Human    64 K-TYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTW 127

  Fly   125 EAHP--GLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLR-------ED 180
            |..|  |:...|:..:|:|:  ..:..:|.|.||.||:|||.:.:||..|..:..|       .:
Human   128 EEDPLAGIIPRTLHQIFEKL--TDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRN 190

  Fly   181 NNGVVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRT 245
            ..||::.||....:::.:|:.::|..|.:.||...|..||.|||||::|.|.|.:.|...|.:..
Human   191 KRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEEL 255

  Fly   246 V---KLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDSNLTRIL 307
            |   ||:::||||||....:..:..|.:|..:||:|||.||..|..|.:...|:|||:|.|||||
Human   256 VKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRIL 320

  Fly   308 KDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKI--RTTLKQNVLKSKMPTEF------- 363
            :|||||..||.::|.:|.:||..|:|.:||:||.|||.|  :..:.|.:.|..:..|:
Human   321 QDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERL 385

  Fly   364 ------------------------------------YVKKIDEVVAENERLKE------------ 380
                                                .::||..|..|..|:.|
Human   386 KRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQC 450

  Fly   381 ----RNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQT 441
                :||..|.:.||....        |.|....|.:.:.:|....:|.:....||:.| ...:|
Human   451 KSDLQNKTQELETTQKHLQ--------ETKLQLVKEEYITSALESTEEKLHDAASKLLN-TVEET 506

  Fly   442 LKKELEEFRKL---MCVDQRVCQ-EDFRRFANYMSTLTSQMEKYKEE------------------ 484
            .|.......||   ..|||...: :|.  |...:::|.:.||:..::
Human   507 TKDVSGLHSKLDRKKAVDQHNAEAQDI--FGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGN 569

  Fly   485 -LPSWLSKME----IAYQDLESLKREVNK--SKAYQILIVYVKYKDLELQLTKQNIFNNHVNAIN 542
             |.|.:|.::    :|...|.|:...|:.  |:.:.:::     |:..|....:.:....:|.:.
Human   570 LLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMIL-----KEQSLAAESKTVLQELINVLK 629

  Fly   543 QELVENLDL---------------MRKSFRTACEVLNQTYDRLEDGQKLTPEIEAVFERLLRKMR 592
            .:|:.:|::               ::..|:|:..|.    |::||.:|   |::.....|...:.
Human   630 TDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVA----DKIEDQKK---ELDGFLSILCNNLH 687

  Fly   593 FADSEANT---------------------KMAEMNPLAVPV--------ALRSSAQEEEEPTCSL 628
              :.:.||                     |......|...:        ||....:..::|..|:
Human   688 --ELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSV 750

  Fly   629 TASAKKR------------QRQAAQSD------------------------DDLHLSMEDFDSQD 657
            ..:.:::            |:..|.||                        |.|:.::|.. ||:
Human   751 QENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKI-SQE 814

  Fly   658 TESDSEELH-RTF-----------KRPRNL-NETQVLGPCSSSSSSSTSSSSSARKALTATVTKP 709
            ||...|.|: ||.           :|.:.| |..:|:..|..:|||..:..|..|||........
Human   815 TEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNI 879

  Fly   710 RTVQQRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQRTLAAASL-AKENVKYNANYVRKSP 773
            ...|..:..|.:..||:. .||.||..|.|.|.|..|.|:..:...:. .:::..|.:..||..|
Human   880 FLDQMTIDEDKLIAQNLE-LNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEP 943

  Fly   774 R 774
            |
Human   944 R 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	131/358 (37%)
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	132/369 (36%)
		PRK12704	350..>508	CDD:237177	30/166 (18%)
		YhaN	380..>761	CDD:443752	61/405 (15%)
		Microtub_bind	916..1053	CDD:464048	6/29 (21%)