DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and Klp61F

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster

Alignment Length:	892	Identity:	229/892 - (25%)
Similarity:	381/892 - (42%)	Gaps:	242/892 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EQHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITK---- 64
            :.:.||:|.|||||.|.||     |.|     |||.:.|            ...|...:|:
  Fly    15 KSNQNIQVYVRVRPLNSRE-----RCI-----RSAEVVD------------VVGPREVVTRHTLD 57

  Fly    65 -RMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSE--- 125
             ::.||.|  |||.|..::...|::....:||::.|||||||:||.||.||.|||.||:|:|
  Fly    58 SKLTKKFT--FDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAE 120

  Fly   126 --------AHPGLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLR--ED 180
                    :..|:....:..|||:::...  .::.:.:||||:|||.:.:||:.....|:|  :|
  Fly   121 LKSSWEDDSDIGIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDD 183

  Fly   181 N---NGVVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITE---RK 239
            :   ..|::.||...|::|.:::.::|..|...|....|..||:|||||.:|.:.:.|.|   ..
  Fly   184 STKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEG 248

  Fly   240 TDTKRTVKLSMIDLAGSE---RAASTKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDS 301
            .|..:..||:::||||||   :|.:.|||.||  |..:||:|||.||..|..|.|...|:|||:|
  Fly   249 EDMLKIGKLNLVDLAGSENVSKAGNEKGIRVR--ETVNINQSLLTLGRVITALVDRAPHVPYRES 311

  Fly   302 NLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRT-------TLKQNVLKSKM 359
            .|||:|::||||..:|.::|.:|......|:|.:||:||.|||.|:.       ..|:.|||.
  Fly   312 KLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKE-- 374

  Fly   360 PTEFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQE 424
                |.::||::..:....:::|....|:.|         :..:.||        :.:..|:|.|
  Fly   375 ----YTEEIDKLKRDLMAARDKNGIYLAEET---------YGEITLK--------LESQNRELNE 418

  Fly   425 HVL---GMRSKIKN------------INYRQTLKKELEEF----------RKLMCVDQRVCQEDF 464
            .:|   .::.:::|            :...|.|||..|..          :|::...:|..:|..
  Fly   419 KMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKK 483

  Fly   465 RRFANYMST---LTSQM----------------------------EKYKEELPSWLSKME----- 493
            ...|::|.|   ||:|.                            ||.:.....:..:|:
  Fly   484 ELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEM 548

  Fly   494 -----IAYQDLESLKRE-----------------VNKSKAYQILIVYVKYKDLELQLTKQN---- 532
                 ..|||.::..:|                 :|.||:.::| ..:..:.|:.|....|
  Fly   549 IGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEML-KEMCAQSLQDQTNLHNKLIG 612

  Fly   533 ----IFNNHVNAINQELVENLD----LMRKSFRTACEVL---NQTYDRLEDGQKLTPEIEAVFER 586
                |.:.|..|...:|:|.:.    ||.|..:|..:|:   ||.:..:.|  .:..:...:.:.
  Fly   613 EVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLD--SMQEKFATIIDS 675

  Fly   587 LLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSM- 650
            .|:.:.....:.:.|:.::..:::|.|......:||          ...:|..||.:|.|..||
  Fly   676 SLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEE----------LANERALAQQEDALLESMM 730

  Fly   651 ------EDFDSQDTESDSEEL-----------HRTFKRPRNLNETQVLGPCSSSSSSSTSSSSSA 698
                  ::..|:::.|.|..|           ||.......:.:.|.||         ..:|.||
  Fly   731 MQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLG---------IEASQSA 786

  Fly   699 RKALTATVTKPRTVQQRLVSDLISDQNV----------RGGNEKIKK 735
            :..||:         |.....|..||.|          :..|:|.:|
  Fly   787 QAELTS---------QMEAGMLCLDQGVANCSMLQVHMKNLNQKYEK 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	137/378 (36%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	135/364 (37%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	136/375 (36%)
		Kinesin	25..356	CDD:278646	131/358 (37%)
		Microtub_bind	923..>1009	CDD:290642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840