DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and unc-104

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster

Alignment Length:	777	Identity:	213/777 - (27%)
Similarity:	347/777 - (44%)	Gaps:	187/777 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQP--YRDITKRMNKK 69
            :::||||||||:|.||:.::.:.||::...:..:.:|            |.|  ..|..||.|
  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNP------------KVPPNTSDSVKRFN-- 52

  Fly    70 LTMEFDRVF------DIDNSNQDL-FEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLG--SE 125
                ||..:      |.|.|.|.: :::....::....:|||..:|.||.|||||::||:|  .|
  Fly    53 ----FDYSYWSHDHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEE 113

  Fly   126 AHPGLTYLTMQDLFDKIQ-AQSDVRKFDVGVSYLEVYNEHVMNLLT--KSGPLKLREDN-NGVVV 186
            ...|:..:..:|||.:|| .::|..|:.|.|||:|:|.|.|.:||.  ..|.|::||.. .|..|
  Fly   114 QQEGIIPMICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYV 178

  Fly   187 SGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTD------TKRT 245
            ..|....:...:::..::..||..||...|:.|..||||||:|.:.  .|:|:.|      |::.
  Fly   179 EDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIF--FTQRRHDLMTNLTTEKV 241

  Fly   246 VKLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLAD---------GLKHIPYRDS 301
            .|:|::||||||||.||...|.|.||||:|||||..||..|:.||:         ....||||||
  Fly   242 SKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDS 306

  Fly   302 NLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVK 366
            .||.:|:::||||.:|.|:|.:|.:.:.|::|.:||:||.|||:|       |.|:.:..:...|
  Fly   307 ALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQI-------VCKAVVNEDANAK 364

  Fly   367 KIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRS 431
            .|.|:..|.::|::   .|:|:..:::..     |.|...|                  |:...:
  Fly   365 LIRELKEEIQKLRD---LLKAEGIEVQEE-----DELTKST------------------VIKSPT 403

  Fly   432 KIKNINYRQT--LKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEI 494
            |.:|.|...|  ...:|:...||:.......:|..:|        |.::...:|.:   .::|.:
  Fly   404 KSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKR--------TEEIRVQREAV---FAEMGV 457

  Fly   495 AYQD---------------LESLKREVNKSKAYQILIVYVKYKDL------------ELQLTKQN 532
            |.::               |.:|..:.|.|   :.|:.|:| :.|            ::||:..:
  Fly   458 AVKEDGITVGVFSPKKTPHLVNLNEDPNLS---ECLLYYIK-EGLTRLGTHEANVPQDIQLSGSH 518

  Fly   533 IFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKLT-PEIEAVFERLL----RKMR 592
            |...|....|    :|..:.....:.|...:|        |:||. ||:.....|::    ...|
  Fly   519 ILKEHCTFEN----KNSTVTLLPHKDAIIYVN--------GRKLVEPEVLKTGSRVILGKNHVFR 571

  Fly   593 FADSEANTKMAEMNPLAVPVALRSSAQEEEEPT-----------C--------SLTASAKKRQRQ 638
            |.:.|      :...|...:...:.|:.|.|.|           |        .|.|..|||.
  Fly   572 FTNPE------QARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRL-- 628

  Fly   639 AAQSDDDLHLSMEDFDSQDTESDS--EELHRTFKRPRNLNETQVLGPCSSSSSSSTSSSSSA 698
                 |:|.   |.:..:..::|.  ||..:|::...:..:.||      ...|.|.|..|:
  Fly   629 -----DNLE---EQYKREKLQADQQFEEQRKTYEARIDALQKQV------EEQSMTMSMYSS 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	138/374 (37%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	137/367 (37%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	140/382 (37%)
		KISc	3..358	CDD:214526	140/381 (37%)
		Kinesin_assoc	355..498	CDD:292801	31/183 (17%)
		FHA	475..574	CDD:238017	24/114 (21%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940