DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and Kif22

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001009645.1	Gene:	Kif22 / 293502	RGDID:	1311886	Length:	657	Species:	Rattus norvegicus

Alignment Length:	652	Identity:	177/652 - (27%)
Similarity:	283/652 - (43%)	Gaps:	163/652 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDIT--KRMNKKLT 71
            ::||||:||:..   |.|:...::.:|..:|                     ::.  ::..:.|.
  Rat    39 VRVAVRLRPFMD---EAKEPPCVRGIDSCSL---------------------EVANWRKYQETLK 79

  Fly    72 MEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQ 136
            .:||..:...::.||::.....|::..:|.|.|.||..||.||||||.|||||...||:....:.
  Rat    80 YQFDAFYGEKSTQQDVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALM 144

  Fly   137 DLFDKIQAQS-DVRKFDVGV--SYLEVYNEHVMNLL-TKSGPLKLREDNNG-VVVSGLCLTPIYS 196
            ||....:.:| :.|.:|:.|  ||||:|.|.|::|| ..||.|.:|||..| :::.||...||.|
  Rat   145 DLLQLTREESAEGRPWDISVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITS 209

  Fly   197 AEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTD-TKRTVKLSMIDLAGSERAA 260
            ..|..:..:..:.:|....|..|..||||||:..|.:...||.|. .:|..||.:|||||||...
  Rat   210 FSEFEQHFLPASRNRVVGATRLNQRSSRSHAVLLVKVEQRERLTPFRQREGKLYLIDLAGSEDNR 274

  Fly   261 STKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSLGGNCRTLMVANVSM 325
            .|...|:|.||..:||.||..||..::.|..||..||||||.|||:|:|||||:..::::||::.
  Rat   275 RTGNQGIRLKESGAINTSLFVLGKVVDALNQGLPRIPYRDSKLTRLLQDSLGGSAHSILIANIAP 339

  Fly   326 SSLTYEDTYNTLKYASRAKKI------RTTLKQNVL-----------------KSKMPTE----- 362
            ....|:||.:.|.:.:|:|::      ..:|:.:.|                 |:|.|.|
  Rat   340 ERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKLPQKELLGPSEAKKAKGPEEESTGS 404

  Fly   363 ---------------------------------------------------------FYVKKIDE 370
                                                                     ..:|.::|
  Rat   405 PESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGSQGIPLLNTPKRERMVLIKTVEE 469

  Fly   371 VVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKI----DAVYAAARQLQEHVL---- 427
            ...|.||||.:.|.||||....|     ..||.|.:...:.:    ....:.|:.|::.|:
  Rat   470 KNLEIERLKMKQKELEAKVLAQE-----ALDPKEKENTPTILQPSSSCSGSVAKPLKKAVVMPLQ 529

  Fly   428 GMRSKIKNINYRQTLKK----ELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSW 488
            .::.:.::.|....|||    :||...:...|::   .||:.........|....:|....|
  Rat   530 RIQKQSESSNKIHLLKKGHKRKLESSHESEAVEK---DEDYWEIQISPELLARGRKKLLHLL--- 588

  Fly   489 LSKMEIAYQDLESLKREVNKSKAYQILI-------VYVKYKDLELQLTKQNIFNNHVNAINQELV 546
               .|.:.:||.||:| :.:.|| |:::       .:.:.:|||           .|..|:.:.|
  Rat   589 ---NEGSARDLRSLQR-IGQKKA-QLIVGWRELHGPFNEVEDLE-----------QVEGISGKQV 637

  Fly   547 EN 548
            |:
  Rat   638 ES 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	125/357 (35%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	124/344 (36%)
Kif22	NP_001009645.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		KISc	38..367	CDD:214526	124/351 (35%)
		KISc_KID_like	38..358	CDD:276827	123/342 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..415		4/26 (15%)
		HHH_3	588..638	CDD:289597	15/68 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810