DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and Kif19a

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001096085.1	Gene:	Kif19a / 286942	MGIID:	2447024	Length:	997	Species:	Mus musculus

Alignment Length:	882	Identity:	252/882 - (28%)
Similarity:	414/882 - (46%)	Gaps:	133/882 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVAVRVRPYNVRELEQKQRSIIKVMD-RSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTM 72
            :.||:||||.:|.|||:....|...|| :..:|.||.|:.|:.           :....:::.:.
Mouse    12 LMVALRVRPISVAELEEGATLIAHKMDEQMVVLMDPMEDPDDI-----------LRAHRSREKSY 65

  Fly    73 EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQD 137
            .||..||...:.:.:::..|..|::.|::|||.:||.||.||.|||:||||::..||:...|:.|
Mouse    66 LFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDHEPGIYVRTLND 130

  Fly   138 LFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKS-GPLKLREDNNGVV-VSGLCLTPIYSAEEL 200
            ||..|:..|:..:::|.:||||:|||.:.:||..: |.|:||||:.||: |:|:......:|:|:
Mouse   131 LFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLNPALGYLELREDSKGVIQVAGITEVSTINAKEI 195

  Fly   201 LRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTV---KLSMIDLAGSERAAST 262
            :::||.||..|||.||.||..||||||:.||.:|...|..:..:.|   :|.||||||||||:.|
Mouse   196 MQLLMKGNRQRTQEPTAANQTSSRSHAVLQVAVRQRSRVKNILQEVRQGRLFMIDLAGSERASQT 260

  Fly   263 KGIGVRFKEGASINKSLLALGNCINKLAD--GLKHIPYRDSNLTRILKDSLGGNCRTLMVANVSM 325
            :..|.|.||||.||:||||||||||.|:|  ..|:|.||||.|||:||||||||.||:|:|::|.
Mouse   261 QNRGQRMKEGAHINRSLLALGNCINALSDKGSNKYINYRDSKLTRLLKDSLGGNSRTVMIAHISP 325

  Fly   326 SSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLK----------- 379
            :|..:|::.|||.||.|||.|||.:|||:|........|...|.::..|.:|||
Mouse   326 ASTAFEESRNTLTYAGRAKNIRTRVKQNLLNVSYHIAQYTSIIADLRGEIQRLKCKIDQQAGRGQ 390

  Fly   380 -----ERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINY- 438
                 :|......:|.....:|..|  |.|:.....::.:.:.....::..:|.:.::...:..
Mouse   391 ARGKLDRGDIRHIQAEVQLHSGQEG--PAEMGQLREQLISAFHEQMDVRRRLLELENQAMEVQID 453

  Fly   439 ----------------RQTLKKELEEFRKLMCVDQRVCQEDFRRFA------------------- 468
                            |:.||.. ||.||     :...:||..:.:
Mouse   454 TSRHLLTIAGWEHEKSRRALKWR-EERRK-----ESYTKEDSEKDSDTGDEPDNLEPPEVASARE 512

  Fly   469 NYMSTLTSQMEKYKEELPSWLSKMEIAYQDL--------ESLKREVNKSKAYQILIVYVKYKDLE 525
            |..:.:..|.:..||:|     .:|...::|        |:|.|.:...:..::|.:..:..:||
Mouse   513 NIAALVGEQKKLRKEKL-----ALEQRCRELRARGRRLEETLPRRIGSEEQREVLSLLCRVHELE 572

  Fly   526 LQLTKQNIFNNHVNAINQELVENLDLMRK--SFRTACEVLNQTYDRLEDGQKL-TP-EIEAVFER 586
            ::.|:   ..:|....:..|....:.:|:  ..|:.|:.:.|...::.|...| .| .:|.::|.
Mouse   573 VENTE---MQSHALLRDSALRHRREAVRRLEQHRSLCDEIIQGQRQIIDDYNLEVPRHLEELYEV 634

  Fly   587 LLRKMRFADSEANTKMAEMN---------PLAVPVALRSSAQEEEEPTCSLTASAKKRQRQAAQS 642
            .||::.....|..|.|..:.         |...|.....:...:.|...:|::.|::.|...
Mouse   635 YLRELEEGSLERATIMDRVASRALQDSSLPKITPAGATLTPDSDLESVKTLSSEAQRPQNNT--- 696

  Fly   643 DDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSSTSSSSSARKALTATVT 707
                      .....|:|:|..:.:...|...:..:.|..|......|..:..:..:.:|.:.:.
Mouse   697 ----------LPPLGTDSESYHVFKASPRAWQVKSSSVPTPPPIQVGSLVTQEAPPQDSLGSQIN 751

  Fly   708 KPRTVQQRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQRTLAAASLAKENVKYNANYVRKS 772
            ......:.|...|:|       :::.|:.|.::...:.:..||  .:.:|..|.....|....:|
Mouse   752 SSPESSENLSEILLS-------HKERKEILTRTKCISVKAAQR--RSRALGTEGRHLLAPATERS 807

  Fly   773 PRALMAKALAGTSTLARKPLGSASKEPPLVKFNRAAS 809
            ..:|.:.:.|..   ||.|...|.|.||......|.|
Mouse   808 SLSLHSLSEADD---ARPPGQLACKRPPSPTLQHAIS 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	161/351 (46%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	157/344 (46%)
Kif19a	NP_001096085.1	KISc_KIP3_like	11..346	CDD:276821	157/344 (46%)
		KISc	14..353	CDD:214526	161/349 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..509		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..704		6/51 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..759		4/40 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..997		17/63 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740