DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and klp6

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001342739.1	Gene:	klp6 / 2539700	PomBaseID:	SPBC1685.15c	Length:	784	Species:	Schizosaccharomyces pombe

Alignment Length:	886	Identity:	255/886 - (28%)
Similarity:	410/886 - (46%)	Gaps:	199/886 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EQHTNIKVAVRVRPYNVREL-------EQKQ----------------------RSIIKVMDRSAL 39
            ::.::|.|||||||:..||.       :.|:                      |.|::|:|.:.|
pombe     2 KEGSSISVAVRVRPFTEREKGLLAETPKSKEFLGDGSLAVSNTSSNTFCTNGIRKIVRVLDDNVL 66

  Fly    40 LFDPDEEDDEFFFQGAKQP----YRDITKRMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVL 100
            :|||.||:.....|.:..|    :||:        ...|||:|..:.|.:|:::..|.||:|:||
pombe    67 IFDPPEENPLAKVQKSLLPAGKRFRDV--------RYAFDRLFGEEASQEDVYKGTTEPLLDSVL 123

  Fly   101 NGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHV 165
            .|||.:||.|||||.|||.|:.|....||:.:|||:.|.|:::........|:.|||||:|||.:
pombe   124 QGYNATVFAYGATGCGKTHTISGRPDDPGIIFLTMRALLDRVEGLKRTMNVDISVSYLEIYNEKI 188

  Fly   166 MNLLT-------KSGPLKLRED-NNGVVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAES 222
            .:||.       |...|.:.|| ...|.|.||......:.||::.:::.|||:||..||:|||.|
pombe   189 RDLLVQDPLSMEKPKSLNICEDAEQNVSVPGLSYFTPTNLEEVMEIIIRGNSNRTMSPTEANAVS 253

  Fly   223 SRSHAIFQVHIRIT------ERKTDTKRTVKL----SMIDLAGSERAASTKGIGVRFKEGASINK 277
            |||||:.|::|..|      :.:::::.:.|:    |.|||||||||::||..|.|..|||:||:
pombe   254 SRSHAVLQIYITQTPKSGEKQEESESQNSHKVRSVFSFIDLAGSERASATKNRGKRLVEGANINR 318

  Fly   278 SLLALGNCINKLADGLK--HIPYRDSNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYA 340
            ||||||||||.|.:..:  |:|||||.|||:||.||||||||.|:..:|.||..|::|:|||||.
pombe   319 SLLALGNCINSLCEPRRRQHVPYRDSKLTRLLKFSLGGNCRTCMIVCISPSSEHYDETHNTLKYG 383

  Fly   341 SRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLEL 405
            :|||.|:|.:.:||:........||:.|.| :.:...:.::..|.|:|...|.:         |:
pombe   384 NRAKNIKTKVSRNVVSVDRHVSEYVRTIYE-LRQKVSILQKRIAEESKQLALNK---------EV 438

  Fly   406 KTWYSKIDAVYAAARQLQEHVLGMRSKIKNI--NYRQTLKKELEEFRKLMCVDQRVCQEDFRRFA 468
            :    ||     ::|:::  :|..||.:||.  ..|...|..:|..|.|..::..:
pombe   439 R----KI-----SSREIK--MLDARSMLKNSFDGSRDLQKSLIEHVRTLRRIEDEI--------- 483

  Fly   469 NYMSTLTSQMEKYKEELPSWLSKME----IAYQDLESLKREVNKSKAY-QILIVYVKYKDLELQL 528
                |||..          |:|..:    ::..:::|:  |...:|.| |..::..|....|:..
pombe   484 ----TLTKM----------WISIAKESDAMSGHNIKSV--ETRLAKLYDQRSLITAKVNPEEICK 532

  Fly   529 TKQNIFNNHVNAINQE--------LVENLDLMRKSFRTACEVLNQTYDRLEDGQKLTPEIEAVFE 585
            |.||..::.|::...|        |.:::||::..      :.||..|...:.:..:.....:.:
pombe   533 TFQNSISHIVSSFKGEGADMYADMLQDDVDLLKSI------IENQILDAKHESETFSSTSRKLIQ 591

  Fly   586 RLLRKMRFADSEA---NTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKRQRQAAQSDDDLH 647
            .|..........|   |..:|......|.:.       ..|||..:....:|.:...
pombe   592 NLFLLFPLLPGNAIDVNESLARAFDQLVGIV-------PSEPTIQVPNLIEKGKAPL-------- 641

  Fly   648 LSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSSTSSSSSARKALTATVTKPRTV 712
            |||                  |:.||           |.|...:.|.|.:||     .:.||...
pombe   642 LSM------------------FEIPR-----------SPSRFKARSPSKAAR-----VLKKPLKK 672

  Fly   713 QQRLVSDLISDQNV-------RGGNEKIKKALLKSNH-------FTAQGLQRTLAAASLAKENVK 763
            :.|. |::.:..:|       :....|::|:|.|.|.       ..::..:.:|.:.||.....|
pombe   673 RVRF-SEVPTTSSVPPVEIKNKDSKPKVEKSLDKHNMNNDRSFLVPSRDARNSLTSLSLHSNVAK 736

  Fly   764 YNANYVRKSPRALMAKALAGTSTLARKPLGSAS-KEPPLVK 803
            ..:::..|.|...::..:   :|..::|:...| ...||.|
pombe   737 NKSSHSSKWPTHTLSPII---TTALKQPVRRISLVSQPLQK 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	165/397 (42%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	163/390 (42%)
klp6	NP_001342739.1	KISc_KIP3_like	6..389	CDD:276821	163/390 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	279	1.000	Domainoid score	I301
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I602
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		otm47087
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X1854
TreeFam	1	0.960	-	-
	11	10.850