Protein Alignment Klp67A and KIF6

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_005248961.1
• Gene: KIF6 / 221458
• HGNCID: 21202
• Length: 842
• Species: Homo sapiens
• Alignment Length: 847
• Identity: 212/847 - (25%)
• Similarity: 372/847 - (43%)
• Gaps: 188/847 - (22%)

  Fly     9 IKVAVRVRPYNVRELEQKQRSI---IKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKL 70
            |::..||:| .||:.:|...||   .|::....::...|..|.  |....::.|:
Human     6 IQIFARVKP-PVRKHQQGIYSIDEDEKLIPSLEIILPRDLADG--FVNNKRESYK---------- 57

  Fly    71 TMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSE---AHPGLTY 132
             .:|.|:||.|.:.:.:||....|:..:||.|||.::|.||.||:|||||:.|..   :..|:..
Human    58 -FKFQRIFDQDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIP 121

  Fly   133 LTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLT---KSGPLK-------LREDNNGVVVS 187
            .|:..:|:::|..|. :.:...:||||:|||...:||.   ::..|:       |.:.:..:.:.
Human   122 RTLSYIFEQLQKDSS-KIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLK 185

  Fly   188 GLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTVKLSMID 252
            .|.|....:.||.|.:|.||:::|....|..|..|:|||.||.:|:...|..:.|.|..||.::|
Human   186 NLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVD 250

  Fly   253 LAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLK-HIPYRDSNLTRILKDSLGGNCR 316
            ||||||.|.|...|....|...||.||..|...|..|::..: |||||:|.:|.:|:|||||||.
Human   251 LAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCM 315

  Fly   317 TLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAE-NERL-- 378
            |.|:|.:|:.....:::.:|.::|.|...|:   .:.||..::.....:|::.:.:.| .:.|
Human   316 TTMIATLSLEKRNLDESISTCRFAQRVALIK---NEAVLNEEINPRLVIKRLQKEIQELKDELAM 377

  Fly   379 ---KERNKAL-EAKATQLERAGNS-------------GFDPLELKTWYSKIDAVYAAARQLQEHV 426
               ::|.:|| ||:..|||:...|             |.|..::...:..:..:....:.|:.:.
Human   378 VTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNT 442

  Fly   427 LGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSK 491
            :...||.::.  ::.||:  ||:|||..:   :.|.|     |.::.|.:.::|.|::..   ..
Human   443 VSSESKDQDC--QEPLKE--EEYRKLRDI---LKQRD-----NEINILVNMLKKEKKKAQ---EA 492

  Fly   492 MEIAYQDLESLKREVNKSKA----------------------YQILIVYVKYKDL---------E 525
            :.:|..|    :||..:|::                      .|...:..|...|         |
Human   493 LHLAGMD----RREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREE 553

  Fly   526 LQLTKQNIF----NNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKLTPEIEAVFER 586
            :.|..|..|    .:|.:::.  :.:|..::::.|..| :.|.::.:  |...|:....|.:.:|
Human   554 MSLGCQEAFEIFKRDHADSVT--IDDNKQILKQRFSEA-KALGESIN--EARSKIGHLKEEITQR 613

  Fly   587 LLRKMRFADSEANTKMAEMNPLAVPV-------ALRSSAQEEE-----------------EPTCS 627
            .::::....||         .:|||:       .|||..:||:                 |....
Human   614 HIQQVALGISE---------NMAVPLMPDQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQL 669

  Fly   628 LTASAK-KRQRQA----AQSDDDLHLSMEDFDSQD------TESDSEELHRTFKRPRN------- 674
            |...|| |.|::.    |:...:|.::....:|.|      ..|||:  |...:...|
Human   670 LMDKAKVKLQKEFEVWWAEEATNLQVNSPAVNSLDHTKPFLQTSDSQ--HEWSQLLSNKSSGGWE 732

  Fly   675 -------------LNETQVL-GPCSS-----SSSSSTSSSSSARKALTATVTKPRTVQQRLVSDL 720
                         :|..::| .||.|     .||:||....|..|...:::  |.|...:..||:
Human   733 VQDQGTGRFDVCDVNARKILPSPCPSPHSQKQSSTSTPLEDSIPKRPVSSI--PLTGDSQTDSDI 795

  Fly   721 IS 722
            |:
Human   796 IA 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	117/353 (33%)
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:473979	117/351 (33%)
		SMC_N	<574..>668	CDD:481474	19/107 (18%)