Protein Alignment Klp67A and unc-104

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_001022041.2
• Gene: unc-104 / 174144
• WormBaseID: WBGene00006831
• Length: 1628
• Species: Caenorhabditis elegans
• Alignment Length: 819
• Identity: 208/819 - (25%)
• Similarity: 367/819 - (44%)
• Gaps: 159/819 - (19%)

  Fly     7 TNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALL--FDPDEED-----DEFFFQGAKQPYRDITK 64
            :::||||||||:|.||:....:.:::|...:..:  ...::|:     |..::..|:.....||:
 Worm     2 SSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSINKENFSFNFDHSYWSFARNDPHFITQ 66

  Fly    65 RMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHP- 128
            :                    .::||....:::....|||..:|.||.||:||::||:|....|
 Worm    67 K--------------------QVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPD 111

  Fly   129 --GLTYLTMQDLFDKIQAQSDVR-KFDVGVSYLEVYNEHVMNLL--TKSGPLKLREDN-NGVVVS 187
              |:......|||.:|...:|.. ::.|.|||:|:|.|.|.:||  ...|.|::||.. .|..|.
 Worm   112 EMGIIPRLCNDLFARIDNNNDKDVQYSVEVSYMEIYCERVKDLLNPNSGGNLRVREHPLLGPYVD 176

  Fly   188 GLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERK------TDTKRTV 246
            .|....:.|..::..::..||..||...|:.|:.||||||:|.  |.:|:::      .||::..
 Worm   177 DLTKMAVCSYHDICNLMDEGNKARTVAATNMNSTSSRSHAVFT--IVLTQKRHCADSNLDTEKHS 239

  Fly   247 KLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLAD----------GLKHIPYRDS 301
            |:|::||||||||.||...|.|.||||:|||||..||..|:|||:          |:  ||||||
 Worm   240 KISLVDLAGSERANSTGAEGQRLKEGANINKSLTTLGLVISKLAEESTKKKKSNKGV--IPYRDS 302

  Fly   302 NLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVK 366
            .||.:|:::||||.:|.|:|.:|.:.:.:::|.:||:||.|||:|   :.|.|: ::.|....::
 Worm   303 VLTWLLRENLGGNSKTAMLAALSPADINFDETLSTLRYADRAKQI---VCQAVV-NEDPNAKLIR 363

  Fly   367 KIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDA-VYAAARQLQEH----- 425
            :::|.|.:...:. ::|.::....| |..|.....|        |:.| |:....:|||.
 Worm   364 ELNEEVIKLRHIL-KDKGIDVTDVQ-ETPGKHKKGP--------KLPAHVHEQLEKLQESEKLMA 418

  Fly   426 VLGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLS 490
            .:|...:.|.|:..:..|:..||.|.:    ...|.||......:.......:....|:  ..:|
 Worm   419 EIGKTWEQKLIHTEEIRKQREEELRDM----GLACAEDGTTLGVFSPKKLPHLVNLNED--PLMS 477

  Fly   491 KMEIAY--QDLESLKREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMR 553
            :..|.|  :.:.|:.|...:.:.             ::.|:.:.|...|...||::  .|:.|..
 Worm   478 ECLIYYLKEGVTSVGRPEAEHRP-------------DILLSGEAILELHCEFINED--GNVTLTM 527

  Fly   554 KSFRTACEVLNQTYDRLEDGQKLTPEIEAVFERLL----RKMRFADSEANTKMAEMNPLAVPVAL 614
            |. ..:|.:..:        |..||.:.....|::    ...|:.|.: ..:.:..|..|:
 Worm   528 KP-NASCYINGK--------QVTTPTVLHTGSRVILGEHHVFRYNDPQ-EARQSRHNLAAI---- 578

  Fly   615 RSSAQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQ----DTESDSEELHRTFKRPRNL 675
                  .|:|.....|..:...:|......|:...|.:.:||    ..|.:.:..|:|.:....:
 Worm   579 ------AEQPIDWKYAQQELLDKQGIDLKADMEKKMLEMESQYRREKVELEQKMYHQTREYESMI 637

  Fly   676 NETQVLGPCSSSSSSSTSSSSSARKALTATVTK-PRTVQQRLVSDLISDQNVRGGNEKIKKALLK 739
            ...|.....:.|..|...|.....:.||:::.: |..::      ..|||         |:.:||
 Worm   638 ENLQKQVDLAQSYISGGGSIWEGERMLTSSLLEFPEELK------WTSDQ---------KRVVLK 687

  Fly   740 S------NHFTAQGLQRTLAAASLAKENVKYNANYVRKS 772
            :      :.||:            .::::..||.:|:::
 Worm   688 AAIKWRYHQFTS------------VRDDLWGNAIFVKEA 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	129/367 (35%)
unc-104	NP_001022041.2	KISc_KIF1A_KIF1B	2..354	CDD:276816	132/379 (35%)
		Kinesin_assoc	351..488	CDD:465047	29/153 (19%)
		FHA_KIF1	464..564	CDD:438757	20/125 (16%)
		Rcc_KIF21	595..652	CDD:425381	10/56 (18%)
		KIF1B	829..875	CDD:463574
		DUF3694	1116..1260	CDD:463599
		PH_KIFIA_KIFIB	1500..1602	CDD:269939