Protein Alignment Klp67A and Kif5b

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_032474.2
• Gene: Kif5b / 16573
• MGIID: 1098268
• Length: 963
• Species: Mus musculus
• Alignment Length: 879
• Identity: 241/879 - (27%)
• Similarity: 383/879 - (43%)
• Gaps: 176/879 - (20%)

  Fly     2 PSEQHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQG------AKQPYR 60
            |:|  .||||..|.||.|..|:.:..:.:.|                   |||      |.:||
Mouse     4 PAE--CNIKVMCRFRPLNESEVNRGDKYVAK-------------------FQGEDTVMIASKPY- 46

  Fly    61 DITKRMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSE 125
                        .|||||....|.:.::.:|...:|..||.|||.::|.||.|.:|||.||.|..
Mouse    47 ------------AFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKL 99

  Fly   126 AHP---GLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGP-LKLREDNNGV-V 185
            ..|   |:....:||:|:.|.:..:..:|.:.|||.|:|.:.:.:||..|.. |.:.||.|.| .
Mouse   100 HDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPY 164

  Fly   186 VSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTVKLSM 250
            |.|.....:.|.:|::..:..|.|:|....|:.|..|||||:||.::::....:|:.|.:.||.:
Mouse   165 VKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYL 229

  Fly   251 IDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSLGGNC 315
            :||||||:.:.|...|....|..:|||||.||||.|:.||:|..::|||||.:||||:|||||||
Mouse   230 VDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNC 294

  Fly   316 RTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKE 380
            ||.:|...|.||....:|.:||.:..|||.|:.|:..||   ::..|.:.||.       |:.||
Mouse   295 RTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNV---ELTAEQWKKKY-------EKEKE 349

  Fly   381 RNKALEAKATQLERAGNSGFDPLELKTWYS----KIDAVY-----------------------AA 418
            :||.|......||.         ||..|.:    .||..:                       ||
Mouse   350 KNKTLRNTIQWLEN---------ELNRWRNGETVPIDEQFDKEKANLEAFTADKDIAITSDKPAA 405

  Fly   419 A------------RQLQEHVLGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYM 471
            |            |:.:|.:..:..::.:.:.....:.:|.|..|...:||.......||..:.|
Mouse   406 AVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNM 470

  Fly   472 ----STLTSQMEKYKEELPSWLSKMEIAYQDLESLKREV-NKSKAYQILIVYVKYK-------DL 524
                :.|.::.:..|||:...|..:|....:.:...:|| :|:|.|::|...:..|       |.
Mouse   471 QAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDA 535

  Fly   525 ELQLTKQNIFNNHVNAINQELVENL--DLMRKSFRTACEVLNQ-----------TYDRLEDGQKL 576
            |||..|:  ..||......|::.:|  ||...........:.|           |..||.. .|:
Mouse   536 ELQKLKE--MTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYI-SKM 597

  Fly   577 TPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLT---ASAKKRQRQ 638
            ..|::.:.:| .:::....:|:|.||.|.........||.|  :.|....|||   .:.::::||
Mouse   598 KSEVKTMVKR-CKQLESTQTESNKKMEENEKELAACQLRIS--QHEAKIKSLTEYLQNVEQKKRQ 659

  Fly   639 AAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSSTSSSSSARKALT 703
            ..:|.|.|...:....:|:...:.|:.|        ||:.|.......:......|.....:...
Mouse   660 LEESVDSLGEELVQLRAQEKVHEMEKEH--------LNKVQTANEVKQAVEQQIQSHRETHQKQI 716

  Fly   704 ATVTKPRTVQQRLVSDLISDQN---------VRGGNEKIK----KALLKSNHFTA---------- 745
            :::......:::|::|| .|||         :|..:|::|    :...|.:..|.
Mouse   717 SSLRDEVEAKEKLITDL-QDQNQKMVLEQERLRVEHERLKATDQEKSRKLHELTVMQDRREQARQ 780

  Fly   746 --QGLQRTLAAA-----SLAKENVKYNANYVRKS 772
              :||:.|:|..     :|.|..|:..|..|:||
Mouse   781 DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKS 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	129/348 (37%)
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	130/352 (37%)
		SMC_prok_B	<417..803	CDD:274008	82/400 (21%)
		Khc_CBD_cc	834..903	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963
		Globular	915..963