Protein Alignment Klp67A and KIF18B

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_011522687.1
• Gene: KIF18B / 146909
• HGNCID: 27102
• Length: 873
• Species: Homo sapiens
• Alignment Length: 919
• Identity: 298/919 - (32%)
• Similarity: 426/919 - (46%)
• Gaps: 198/919 - (21%)

  Fly     5 QHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAK-QPYRDITKRMNK 68
            :.:.::|.|||||...|||:.::|.:::|:|...|:|:|:|.|..  |.|.| ....|..|:..|
Human    13 EDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGG--FPGLKWGGTHDGPKKKGK 75

  Fly    69 KLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYL 133
            .||..|||||....:.||:|:..|..::|:.|.|||||||.|||||||||.||||.|..||:.||
Human    76 DLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYL 140

  Fly   134 TMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLRED-NNGVVVSGLCLTPIYSA 197
            |..:|:.:::|:...:.|:|.:||.|||||.:.:||...|||.:||| :.||||.||......||
Human   141 TTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASA 205

  Fly   198 EELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITER---KTDTKRTVKLSMIDLAGSERA 259
            |:||.:|..||.:||||||||||.|||||||||:.::..:|   .|...:..|:|:|||||||||
Human   206 EQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERA 270

  Fly   260 ASTKGIGVRFKEGASINKSLLALGNCINKLAD--GLK-HIPYRDSNLTRILKDSLGGNCRTLMVA 321
            :||...|.|.:|||:||:|||||.|.:|.|||  |.| |:|||||.|||:|||||||||||:|:|
Human   271 SSTHAKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIA 335

  Fly   322 NVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALE 386
            .:|.|||||||||||||||.|||:||.:||.||.........|.....::.||...|:::.:..|
Human   336 AISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYE 400

  Fly   387 A----KATQLERAGNSGFDPLELKTWYSKI----------DAVYAAARQLQEHVLGMRSKIKNIN 437
            .    ....|..:..||..|..|.:  |.:          ..:.|..|.|||..|||.:::
Human   401 GGGQPPPQDLPGSPKSGPPPEHLPS--SPLPPHPPSQPCTPELPAGPRALQEESLGMEAQV---- 459

  Fly   438 YRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESL 502
                     |...:....||....||             :.|...||:|:.:.:....:...||.
Human   460 ---------ERAMEGNSSDQEQSPED-------------EDEGPAEEVPTQMPEQNPTHALPESP 502

  Fly   503 KREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTY 567
            :..:....    ::.:...::|:...:||                      .:.:..| |..:.|
Human   503 RLTLQPKP----VVGHFSARELDGDRSKQ----------------------LALKVLC-VAQRQY 540

  Fly   568 DRLEDGQKLTPEIEAVFERLLRKMR------FADSEANTKMAEMNPLA-------VPV------- 612
            ..|:....|||::...||.|.:.::      .|::...:.:|...|||       :||
Human   541 SLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESIPVPSPLCPE 605

  Fly   613 -------ALRSSAQE----------EEEPTCSLTASA-----KKRQRQAAQSDDDLHLSMEDFDS 655
                   ..|:.|:.          ...|.|:....:     |||:|.:|
Human   606 PPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPAQGSRWPMEKKRRRPSA--------------- 655

  Fly   656 QDTESDSEEL-HRTFKRPR----------NLNETQVLGPCSSSSSSSTSSSSSARKALTATVTKP 709
              .|:||... .|..||.|          :|.:||.....|:......||...:.:...|||.|.
Human   656 --LEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIKS 718

  Fly   710 R------------------TVQQRLVSDLISDQNVRG------GNEKIKKALLKSNH-------- 742
            |                  |.......||..:...:.      |.:||.:.|.:.:.
Human   719 RVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIPRAPV 783

  Fly   743 --FTAQGLQRT--LAAAS------LAKENVKYNANYVRKSPRALMAKALAGTSTLARKPLGSASK 797
              ||.:|.:.|  |...|      :|..:|.:..:.:.:.|.:.: |..||...|...||.
Human   784 PLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTL-KRPAGPLVLPELPLS---- 843

  Fly   798 EPPLVKFNR 806
              ||...||
Human   844 --PLCPSNR 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	189/345 (55%)
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	189/345 (55%)
		PHA03247	<606..851	CDD:223021	53/269 (20%)