DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp67A and KIF19

DIOPT Version :9

Sequence 1:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_016879639.1	Gene:	KIF19 / 124602	HGNCID:	26735	Length:	1012	Species:	Homo sapiens

Alignment Length:	905	Identity:	253/905 - (27%)
Similarity:	415/905 - (45%)	Gaps:	164/905 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVAVRVRPYNVRELEQKQRSII-KVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTM 72
            :.||:||||.:|.|||:....|. ||.::..:|.||.|:.|:.           :....:::.:.
Human    12 LMVALRVRPISVAELEEGATLIAHKVDEQMVVLMDPMEDPDDI-----------LRAHRSREKSY 65

  Fly    73 EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQD 137
            .||..||...:.:.:::..|..|::.|::|||.:||.||.||.|||:||||::..||:...|:.|
Human    66 LFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDQEPGIYVQTLND 130

  Fly   138 LFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKS-GPLKLREDNNGVV-VSGLCLTPIYSAEEL 200
            ||..|:..|:..:::|.:||||:|||.:.:||..| |.|:||||:.||: |:|:......:|:|:
Human   131 LFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLNPSLGYLELREDSKGVIQVAGITEVSTINAKEI 195

  Fly   201 LRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTV---KLSMIDLAGSERAAST 262
            :::||.||..|||.||.||..||||||:.||.:|...|..:..:.|   :|.||||||||||:.|
Human   196 MQLLMKGNRQRTQEPTAANQTSSRSHAVLQVTVRQRSRVKNILQEVRQGRLFMIDLAGSERASQT 260

  Fly   263 KGIGVRFKEGASINKSLLALGNCINKLAD--GLKHIPYRDSNLTRILK-------------DSLG 312
            :..|.|.||||.||:||||||||||.|:|  ..|:|.||||.|||:||             ||||
Human   261 QNRGQRMKEGAHINRSLLALGNCINALSDKGSNKYINYRDSKLTRLLKVPATAGPGHWAPRDSLG 325

  Fly   313 GNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENER 377
            ||.||:|:|::|.:|..:|::.|||.||.|||.|:|.:|||:|........|...|.::..|.:|
Human   326 GNSRTVMIAHISPASSAFEESRNTLTYAGRAKNIKTRVKQNLLNVSYHIAQYTSIIADLRGEIQR 390

  Fly   378 LKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHV-------LGMRSKIKN 435
            ||.:......:.....|........::.:..........|...||:|.:       :.:|.::..
Human   391 LKRKIDEQTGRGQARGRQDRGDIRHIQAEVQLHSGQGEKAGMGQLREQLASAFQEQMDVRRRLLE 455

  Fly   436 INYRQTLKKELEEFRKLMCV----------------DQR---VCQEDFRR--------------- 466
            :..| .::.:::..|.|:.:                :||   ..::|..:
Human   456 LENR-AMEVQIDTSRHLLTIAGWKHEKSRRALKWREEQRKECYAKDDSEKDSDTGDDQPDILEPP 519

  Fly   467 -FANYMSTLTSQMEKYKEELPSWLSKMEIAYQDL------------ESLKREVNKSKAYQILIVY 518
             .|....::.:.:::.|:     |.|.::|.:..            |:|.|.:...:..::|.:.
Human   520 EVAAARESIAALVDEQKQ-----LRKQKLALEQRCRELRARGRRLEETLPRRIGSEEQREVLSLL 579

  Fly   519 VKYKDLELQLTKQN---IFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQ---KLT 577
            .:..:||::.|:..   :..:.......|.|..|:    ..|:.|:.:.|...::.|..   .:.
Human   580 CRVHELEVENTEMQSHALLRDGALRHRHEAVRRLE----QHRSLCDEIIQGQRQIIDADYNLAVP 640

  Fly   578 PEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPT-CSLTASAKKRQRQAAQ 641
            ..:|.::|..||::    .|.:.:.|.:.......||:.|:..:..|. .|||..:.....:...
Human   641 QRLEELYEVYLREL----EEGSLEQATIMDQVASRALQDSSLPKITPAGTSLTPDSDLESVKTLS 701

  Fly   642 SDDDLHLSMEDFDSQDTESDSEELHRTFKR----------------PRNLNE--TQVLGPCSSSS 688
            ||.. ||.........|||:.   |..||.                |..|..  ||. .|...|.
Human   702 SDAQ-HLQNSALPPLSTESEG---HHVFKAGTGAWQAKSSSVPTPPPIQLGSLVTQE-APAQDSL 761

  Fly   689 SSSTSSSSSARKALTATVTKPRTVQQRLVSDLISDQN---VRGGNEKIKKALLKSNHFTAQGLQR 750
            .|..:||..:.:.|:..   |.:.::|  .::::...   |:....:.:....:..|..|...:|
Human   762 GSWINSSPDSSENLSEI---PLSHKER--KEILTGTKCIWVKAARRRSRALGTEGRHLLAPATER 821

  Fly   751 -TLAAASLAKENVKYNANYVRKSPRALMAKALAGTSTLARKPLGSASKEPPLVKFNRAAS 809
             :|:..||::.:.                         ||.|...|.|.||......|||
Human   822 SSLSLHSLSEGDD-------------------------ARPPGPLACKRPPSPTLQHAAS 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	161/364 (44%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	158/357 (44%)
KIF19	XP_016879639.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740