Protein Alignment Klp67A and KIF1C

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_006603.2
• Gene: KIF1C / 10749
• HGNCID: 6317
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1002
• Identity: 248/1002 - (24%)
• Similarity: 398/1002 - (39%)
• Gaps: 282/1002 - (28%)

  Fly     8 NIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDE--------------------EDDEFFF 52
            ::||||||||:|.||..|..:.::.:...:..:.:|.:                    ||.:|..
Human     5 SVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSTEDPQFAS 69

  Fly    53 QGAKQPYRDITKRMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGK 117
            |  :|.||||.:.|                            |:.| ..|||..:|.||.|||||
Human    70 Q--QQVYRDIGEEM----------------------------LLHA-FEGYNVCIFAYGQTGAGK 103

  Fly   118 TFTMLGSE--AHPGLTYLTMQDLFDKI-QAQSDVRKFDVGVSYLEVYNEHVMNLLT-KS-GPLKL 177
            ::||:|.:  ...|:.....:|||.:: :.||....:.|.|||:|:|.|.|.:||. || |.|::
Human   104 SYTMMGRQEPGQQGIVPQLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRV 168

  Fly   178 REDN-NGVVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQV------HIRI 235
            ||.. .|..|..|....:.|..::..::..||..||...|:.|..||||||:|.:      |.::
Human   169 REHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQL 233

  Fly   236 TERKTDTKRTVKLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLAD------GLK 294
            |  ..|:::..|:|::||||||||.|:...|:|.||||:|||||..||..|:.|||      ...
Human   234 T--GLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSD 296

  Fly   295 HIPYRDSNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKM 359
            .||||||.||.:||::||||.||.|:|.:|.:.:.||:|.:||:||.|.|:||.    |.:.::.
Human   297 FIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRC----NAIINED 357

  Fly   360 PTEFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQE 424
            |....::::.|.||   ||:|...|....|:.||          .|||....:.....|......
Human   358 PNARLIRELQEEVA---RLRELLMAQGLSASALE----------GLKTEEGSVRGALPAVSSPPA 409

  Fly   425 HVLGMRSKIKN--------------INYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLT 475
            .|........|              |...:.::: |:|..|::.......:|..|:        |
Human   410 PVSPSSPTTHNGELEPSFSPNTESQIGPEEAMER-LQETEKIIAELNETWEEKLRK--------T 465

  Fly   476 SQMEKYKEELPSWLSKMEIAYQD---------------LESLKRE--VNKSKAYQIL--IVYVKY 521
            ..:...:|.|   |::|.:|.::               |.:|..:  :::...|.|.  :..|..
Human   466 EALRMEREAL---LAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQ 527

  Fly   522 KDLELQLTKQNIFNNH--VNAINQ---ELVENLD-----------------LMRKS--------- 555
            .|::::||.|.|...|  ..:|.|   |:|..|:                 |:.||
Human   528 VDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKN 592

  Fly   556 --FR------------------------------TACEVLNQ--------TYDRLEDGQKLTPEI 580
              ||                              ...|:|.|        ...||:|.:....:.
Human   593 HVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKE 657

  Fly   581 EAVFERLLRKMR-FADSEANTKMAEMNPLAVPVALRSSAQEEEEPT--------CSLTASAKKR- 635
            :...:.||.:.| :|||::... ::.........|.||.:|:..||        |.|.:|.|:|
Human   658 KEEADLLLEQQRLYADSDSGDD-SDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRRA 721

  Fly   636 --------QRQAAQSDDDLHLSMEDFDSQDTES-----------------------DSEELHRTF 669
                    ||:..|..|....:|.|...|..:.                       ...||.||:
Human   722 PRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTY 786

  Fly   670 KRP-----------RNLNET---QVLGPCSSSSSSSTSSSSSARKALTATVTKPRTVQQRL-VSD 719
            .:|           |::.:|   :..|...|...|...:..:..:.|.|.:.|...:.|.: :.:
Human   787 GKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQN 851

  Fly   720 LISDQNVRGGNEKIKKALLKSNHFTAQGLQRTLAAASLAKENVKYNANYVRKSPRALMAKALAGT 784
            ...|:.::...:::.:            ::|.:..|...::..:.........|....|...|..
Human   852 SSKDRELQALRDRMLR------------MERVIPLAQDHEDENEEGGEVPWAPPEGSEAAEEAAP 904

  Fly   785 S---TLARKPLGSASKEPPLVKFNRAA 808
            |   ..||.|      .|||..:.|.:
Human   905 SDRMPSARPP------SPPLSSWERVS 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	137/375 (37%)
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	140/386 (36%)
		Kinesin_assoc	352..522	CDD:465047	33/194 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..438		4/37 (11%)
		FHA_KIF1C	498..599	CDD:438780	21/100 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..828		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..924		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1103