Protein Alignment Klp67A and kif3b

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_001093615.1
• Gene: kif3b / 100101641
• ZFINID: ZDB-GENE-050119-3
• Length: 775
• Species: Danio rerio
• Alignment Length: 865
• Identity: 230/865 - (26%)
• Similarity: 375/865 - (43%)
• Gaps: 159/865 - (18%)

  Fly     3 SEQHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMN 67
            |:...::||.||.||.|.:|.......::.|              |....|.|....|..:...:
Zfish     4 SKSSESVKVVVRCRPMNEKERVANFNRVVSV--------------DVKLGQVAVCNPRGASSHEH 54

  Fly    68 KKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHP---G 129
            .|: ..||.|:|.::...:|::|...||||:||.|:|.::|.||.||.|||:||.|....|   |
Zfish    55 PKV-FTFDSVYDWNSKQMELYDETFRPLVDSVLFGFNGTIFAYGQTGTGKTYTMEGVRNDPERRG 118

  Fly   130 LTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTK--SGPLKLRE-DNNGVVVSGLCL 191
            :...:.:.:|..|.. |..:::.|..||||:|.|.:.:||:|  :..|:|:| .:.||.|..|..
Zfish   119 VIPNSFEHIFTHISC-SQNQQYLVRASYLEIYQEEIRDLLSKDQARRLELKERPDTGVYVKDLSS 182

  Fly   192 TPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTK---RTVKLSMIDL 253
            ....|..|:..::.:||.:|:...|:.|..||||||||.:.|..:|...|.:   |..||:::||
Zfish   183 FVTKSVREIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSELGPDGENHIRVGKLNLVDL 247

  Fly   254 AGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLK-HIPYRDSNLTRILKDSLGGNCRT 317
            |||||...|...|.|.||...||.||.||||.|:.|.||.. |||||||.|||:|:||||||.||
Zfish   248 AGSERQTKTGAQGERLKEATKINLSLSALGNVISALVDGRSTHIPYRDSKLTRLLQDSLGGNART 312

  Fly   318 LMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERN 382
            :||||:..:|...|:|..||:||:|||.|:...:.|    :.|.:..:::..|.:|..:...|:.
Zfish   313 VMVANIGPASYNVEETLTTLRYANRAKNIKNKPRVN----EDPKDALLREFQEEIARLKEQLEKR 373

  Fly   383 KALEAKATQLERAGNSG--FDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNI-NYRQTLKK 444
            ...:.:..:..|.|..|  |:..|.:......|         ::...|:.:. ||| :|....::
Zfish   374 SGRKRRRRRRRRVGEGGEEFEDGEDEEDDDDDD---------EDEEEGVDAD-KNIADYWHEQQE 428

  Fly   445 ELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKE-------ELPSWLSKMEIAYQDLESL 502
            :||:.|:.:..|..:..|:.:|.........:.:.|.||       ::.:..||:.:..:::...
Zfish   429 KLEKERRAIMEDHSLVAEEKQRLLKEKERKMTDLHKEKEASEMLTAKVKAMESKLLVGGKNIVDH 493

  Fly   503 KREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVE----------NLDLMRKSFR 557
            ..|..|       ::.:|.:::..|..::......:...::|.:|          .:|:..|..:
Zfish   494 TNEQQK-------VLELKRQEIAEQKRREREMKQEMECRDEETLELKETYSSLQQEVDIKTKKLK 551

  Fly   558 TACEVLNQTYDRLEDGQ----KLTPEIEAVFERLLR--KMRFADSEANTKMAEMNPLAVPVALRS 616
            .....|......::|.|    |...|:|.....|.|  |::....|....|.|.|.:......
Zfish   552 KLFSKLQSVKSEIQDAQDEHVKYRQELEQTQNELTRELKLKHLIIENFIPMEEKNKIVTRATF-- 614

  Fly   617 SAQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVL 681
               :||:....:|...:      .|:.|                     |:..|||
Zfish   615 ---DEEDDLWKMTPITR------IQNSD---------------------HQMMKRP--------- 640

  Fly   682 GPCSSSSSSSTSSSSSARKALTATVTKPRTVQQRLVSDLISDQNVRGGNEK-------------- 732
               .|:.......|..||.|:   :.:| .|:.:..:.|:.:.::.....|
Zfish   641 ---VSAVGYRRPLSQHARMAM---LMRP-DVRYKAENILLLELDLPSRTTKDYEGPVIAPKVAAA 698

  Fly   733 IKKALLKSNHF--TAQGLQRTL--------AAASLAKENVKYNANYVRKSPRALMAKALAGTSTL 787
            ::.||.:.:..  .|.|...:|        :||..:|:         .||.|....|.:: |.|.
Zfish   699 LEDALREEDEIQVDASGFHASLGSSPGLSASAAGFSKK---------PKSGRPKTGKKVS-TPTS 753

  Fly   788 ARKPL-GSASKEPPLVKFNR 806
            |..|| ||.|   ||...:|
Zfish   754 AHSPLSGSGS---PLYPQSR 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	139/347 (40%)
kif3b	NP_001093615.1	KISc_KIF3	15..341	CDD:276822	136/341 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..419		8/56 (14%)
		Mplasa_alph_rch	<425..>611	CDD:275316	32/192 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..775		19/68 (28%)