DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRRF1 and MRRF

DIOPT Version :9

Sequence 1:	NP_648302.2	Gene:	mRRF1 / 39067	FlyBaseID:	FBgn0035980	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001333268.1	Gene:	MRRF / 92399	HGNCID:	7234	Length:	283	Species:	Homo sapiens

Alignment Length:	250	Identity:	87/250 - (34%)
Similarity:	141/250 - (56%)	Gaps:	23/250 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LHLAALGVRQTRVSSSSPKLPLILQNNLENTKYLQVARDYAKGKDKKKEKGGKGK-PGKVEINEQ 69
            :|....|.||....|:.|                  .|.:|..|.|.|   |||: ..:|.||..
Human    55 VHERQHGHRQYMAYSAVP------------------VRHFATKKAKAK---GKGQSQTRVNINAA 98

  Fly    70 QLREILNFDGLNSQMQKSVMQMKEDFVKHLSLRSTSGAIDTLRIKVDGQEHELQELAQISRKNPK 134
            .:.:|:|.:.:|.:|:..:..:|::|.|.|::|::.|::|.:.:.....:..|.:::|||.|:|:
Human    99 LVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQ 163

  Fly   135 TIIVNMIGFPQTIPDVLKAIEKSGMNLNPQQDGTTLFIPIPKVTKEHRENLSKNAKALFVKYRDA 199
            .|:|||..||:.....:|||.:|||||||:.:||.:.:|||:||:||||.|.|.||....|.:|:
Human   164 LILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDS 228

  Fly   200 IRGVQNEHIRKLKKQPELGKDDAF-AAQAQVTAIADRFISEADKLLASKQKELLG 253
            :|.|:...:.||||..:...:|.. ..:.|::.:||..::|.|:.||.|.|||||
Human   229 LRKVRTNSMNKLKKSKDTVSEDTIRLIEKQISQMADDTVAELDRHLAVKTKELLG 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF1	NP_648302.2	RRF	76..252	CDD:238288	66/176 (38%)
MRRF	NP_001333268.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143206
Domainoid	1	1.000	125	1.000	Domainoid score	I5510
eggNOG	1	0.900	-	-		E1_COG0233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12203
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4427
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62479
OrthoDB	1	1.010	-	-		D1472838at2759
OrthoFinder	1	1.000	-	-		FOG0003951
OrthoInspector	1	1.000	-	-		oto89832
orthoMCL	1	0.900	-	-		OOG6_101101
Panther	1	1.100	-	-	LDO	PTHR20982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2772
SonicParanoid	1	1.000	-	-		X5763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800