DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment UGP and Uap1l1

DIOPT Version :9

Sequence 1:	NP_648300.3	Gene:	UGP / 39065	FlyBaseID:	FBgn0035978	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001127988.1	Gene:	Uap1l1 / 296560	RGDID:	1310630	Length:	507	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	117/548 - (21%)
Similarity:	195/548 - (35%)	Gaps:	140/548 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RPIDVLLERAGVRGH------QRAPSDSKEFHEVTKRDAL--RLLEHDVDRLLETTEKARQPALK 62
            |.:...|:||| :.|      ..||.         .|.||  .|...:.|.|.|..::|...:..
  Rat     5 RDVRAKLQRAG-QDHLLRFWADLAPE---------LRAALLAELSSLEADALREHCQRASAASAL 59

  Fly    63 AEMGRFADLFGRFIQEEGPALDWNKIQKLPE----NAVMNYSNLKSPKNEQNEIRNMLDKLVVIK 123
            |. |...||..|             :|.||.    :|:......:....|:...:..|:|:.|:.
  Rat    60 AS-GPLPDLAAR-------------LQPLPPERLGSAIRCDQETRLRWEEEGFRQIALNKVAVLL 110

  Fly   124 LNGGLGTSMGCHGPKSV--IPVRSDLTFLDLTVQQIEHLNK-------TYDANVPLVLMNSFNTD 179
            |.||.||.:|...||.:  :.:.|..|...|..::|..:.:       |: ..||..:|.|..|.
  Rat   111 LAGGQGTRLGVTYPKGMYQVGLPSQKTLYQLQAERIRRVQQLAGQRLGTH-CTVPWYIMTSEFTL 174

  Fly   180 EDTEKIVRKYKGFRV---QIHTFNQSCFPRISREHYLPVAKDFDVEKDMEAWYPPGHGDFYDTFR 241
            ..|.|..:::..|.:   .:..|.|...|.::.|     .|.....||..|..|.|:|..|....
  Rat   175 GPTIKFFKEHDFFHLDPANVVLFEQRMLPAVTFE-----GKAILERKDKVAMAPDGNGGLYCALA 234

  Fly   242 NSGLLKKFIEEGREYCFLSNIDNL----------------GATVDLNILNKLVGEERATTPVEFV 290
            :..:|:...:.|.|:..:..:||:                ||.....::.|...||    ||
  Rat   235 DHQILEDMEQRGVEFVHVYCVDNILVRLADPAFIGFCVLQGADCGAKVVEKAYPEE----PV--- 292

  Fly   291 MEVTDKTRADVKGGTLIQMENKLRLLEIAQVPPEHVDDFKSVKTFKFFNTNNI---WANLAAIDR 352
                         |.:.|::...:::|.:::.|| :...........:|..||   :.....:|.
  Rat   293 -------------GVVCQVDGVPQVVEYSEISPE-IARQCGADGGLLYNAGNICNHFFTRGFLDM 343

  Fly   353 VLRERTLNMEIIVNNKTL----ENGTRV-------IQLETAVGAAMKCFDGAIGINVPR-SRFLP 405
            |:||....:::.|..|.:    |.|..|       |::|..|...:......:...|.| ..|.|
  Rat   344 VIREFEPLLKLHVAVKKVPYVDEEGNLVKPLRPNGIKMEKFVFDVLPFAKNFVAFEVCREEEFSP 408

  Fly   406 VKK-----------SSDLLLVMSNLYTLKNGSLVM-----------------SPQRMFPTTPLVK 442
            :|.           |...|||....:.|:.|:..:                 .|..:...:|||.
  Rat   409 LKNADTADRDNPSTSRRALLVQHYRWALQAGAHFLDVHGVQLPEQSGLLPNGDPPAICEISPLVS 473

  Fly   443 L-GENHFSKVKEFL-GRFANIPDIIELD 468
            . ||.    ::.:| ||....|.|::.|
  Rat   474 YSGEG----LETYLQGRKLQSPFILDED 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UGP	NP_648300.3	UDPGP	68..485	CDD:396322	99/478 (21%)
Uap1l1	NP_001127988.1	UDPGlcNAc_PPase	92..413	CDD:133036	74/347 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4284
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810