DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PGRP-LF and PGLYRP4

DIOPT Version :9

Sequence 1:	NP_648299.3	Gene:	PGRP-LF / 39064	FlyBaseID:	FBgn0035977	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_065126.2	Gene:	PGLYRP4 / 57115	HGNCID:	30015	Length:	373	Species:	Homo sapiens

Alignment Length:	312	Identity:	95/312 - (30%)
Similarity:	143/312 - (45%)	Gaps:	29/312 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LDRSEWLGEPPSGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNF 124
            :.|..| |....|....|..||:.::|||.....|..:.||..|::.:||.|:.:....|:.|||
Human    56 VSRKAW-GAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNF 119

  Fly   125 LVGGDGQIYVGRGWHIQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHRLQP 189
            |||.||::|.|.||:|||.|..||..||:..||.||.....|....:.|.:.|:...|:...|..
Human   120 LVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKGHLSS 184

  Fly   190 DYHIYAHRQLSPTESPGQKLFELMQNWPRFTQDPTSLRLLSNETVKIVTRPYWLAQPPIVPLTPL 254
            .|       :.|....|:....     ||   ..|||:   .....:|.|..|.|:....|  .:
Human   185 SY-------VQPLLGKGENCLA-----PR---QKTSLK---KACPGVVPRSVWGARETHCP--RM 229

  Fly   255 KLPIESVRFVATNTPSCFTQAECTFRVRLLQNWHIESNGYKDINYNFVAAGDENIYEARGWD--H 317
            .||.:....:.|...:|....||...||.:|:::|:.....||.|||:...|..|||..||:  .
Human   230 TLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQG 294

  Fly   318 SCEPPKDADELVVAFIG------PSSSNKKIALELIKQGIKLGHISKNYSLI 363
            |..|..|...|.:.|:|      |:::..:.|.:||:..:..|:::.||.|:
Human   295 SSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLV 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGRP-LF	NP_648299.3	PGRP	57..199	CDD:128941	48/138 (35%)
PGRP-LF	NP_648299.3	PGRP	236..363	CDD:295442	39/134 (29%)
PGLYRP4	NP_065126.2	PGRP	53..194	CDD:128941	49/145 (34%)
		PGRP	211..351	CDD:128941	40/138 (29%)
		Interaction with murein	293..302		2/8 (25%)
		Interaction with murein	353..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5479
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4488
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800