DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PGRP-LF and Pglyrp4

DIOPT Version :9

Sequence 1:	NP_648299.3	Gene:	PGRP-LF / 39064	FlyBaseID:	FBgn0035977	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001159440.1	Gene:	Pglyrp4 / 384997	MGIID:	2686324	Length:	375	Species:	Mus musculus

Alignment Length:	373	Identity:	102/373 - (27%)
Similarity:	161/373 - (43%)	Gaps:	62/373 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LLYFCVILLMVVGLAAGYFMWMMSFSTHSPNKGLH----------------------ILDRSEWL 66
            ||.|.:::|    ||.|...| .:..|...::||.                      ::.|.||
Mouse     5 LLVFSILVL----LAQGVSSW-ENPQTDQVSEGLQQLFGNISQLFEKGILGRDDVFTMVSREEW- 63

  Fly    67 GEPPSGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQ 131
            |....|....|..||..::|||.....|..:.||..:::.:||:|:.: .|.|:.||||||.||:
Mouse    64 GAEAIGCSSKLSRPVDVLVIHHIPGLECHNKTVCSQKLRELQAYHIHN-SWCDVAYNFLVGDDGR 127

  Fly   132 IYVGRGWHIQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHRLQPDYHIYAH 196
            :|.|.||::||.|..||..||:.:||.||.....|....:.|.|.|:...|:...|...   |..
Mouse   128 VYEGVGWNVQGSHDQGYKNISLGVAFFGTQEGHSPSPVALSAMKGLISYAVKKGHLSSK---YIQ 189

  Fly   197 RQLSPTES---PGQKLFELMQNWPRFTQDPTSLRLLSNETVKIVTRPYWLAQPPIVPLTPLKLPI 258
            ..|:.:|.   |.||..:.....|.                 ||.|..|.|:..  ..:.:.||.
Mouse   190 PLLAKSEDCLVPPQKGKQKKAACPH-----------------IVPRSVWGARDS--HCSRMTLPA 235

  Fly   259 ESVRFVATNTPSCFTQAECTFRVRLLQNWHIESNGYKDINYNFVAAGDENIYEARGWDHSCEPPK 323
            :....:.|...:|....||...||.||::.:......||.|||:...|..:||..||::......
Mouse   236 KYAIILHTAGRTCSQPDECRLLVRDLQSFFMNRLNACDIGYNFLVGQDGGVYEGVGWNNQGSKTD 300

  Fly   324 DADE--LVVAFIG------PSSSNKKIALELIKQGIKLGHISKNYSLI 363
            ..::  |.:.|:|      |:::..:.|.:||:..:..|:::.||.|:
Mouse   301 SYNDISLSITFMGTFTGSPPNAAALEAAQDLIRCAVVKGYLTPNYLLM 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGRP-LF	NP_648299.3	PGRP	57..199	CDD:128941	50/163 (31%)
PGRP-LF	NP_648299.3	PGRP	236..363	CDD:295442	35/134 (26%)
Pglyrp4	NP_001159440.1	PGRP	58..192	CDD:128941	49/138 (36%)
		PGRP	213..353	CDD:128941	37/155 (24%)
		Interaction with murein. /evidence=ECO:0000250	295..304		0/8 (0%)
		Interaction with murein. /evidence=ECO:0000250	355..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5479
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4580
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.800