DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4483 and ZDHHC18

DIOPT Version :9

Sequence 1:	NP_648294.1	Gene:	CG4483 / 39057	FlyBaseID:	FBgn0035970	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_115659.1	Gene:	ZDHHC18 / 84243	HGNCID:	20712	Length:	388	Species:	Homo sapiens

Alignment Length:	263	Identity:	64/263 - (24%)
Similarity:	108/263 - (41%)	Gaps:	55/263 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GPITLLTLTLIVTWTVIHMNSMWWAPGSSLESVLNYALIWIQTFGTLYNFIRSLMV-----GPGF 75
            |.:..|||.||:|.|.:..  ::..|..:.:..|...:|    ...|:.|:.|.::     .||.
Human    91 GGVFALTLLLILTTTGLFF--VFDCPYLARKLTLAIPII----AAILFFFVMSCLLQTSFTDPGI 149

  Fly    76 VPLKW--------------------HPQLTKDKMF------LQFCTRCNGYKAPRSHHCRRCNRC 114
            :|...                    .|..|::.:.      |::|..|..::.||:.||..|:.|
Human   150 LPRATVCEAAALEKQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRPPRTSHCSVCDNC 214

  Fly   115 VMKMDHHCPWINTCVGWSNQDSFVYFL--LFFMSGSIHGGIIIVSAVIRGIKKRWLIRYGLRHMA 177
            |.:.||||||:..|||..|...|..|:  |.|::.      .|.:.|:..:..|   ..|...::
Human   215 VERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTA------FIFACVVTHLTLR---AQGSNFLS 270

  Fly   178 TVHLTQTN---LLACVFSLGVIMGTVLASIKLLYMQMKSILKNQTEIENWIVKKAAFRR-NAYPR 238
            |:..|..:   |:.|.||:..|:|  |:... .|:...::..|:....:|..|:..... |.|..
Human   271 TLKETPASVLELVICFFSIWSILG--LSGFH-TYLVASNLTTNEDIKGSWSSKRGGEASVNPYSH 332

  Fly   239 KGI 241
            |.|
Human   333 KSI 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4483	NP_648294.1	zf-DHHC	88..224	CDD:279823	39/146 (27%)
ZDHHC18	NP_115659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		zf-DHHC	191..314	CDD:279823	39/134 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810