DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4483 and Zdhhc1

DIOPT Version :9

Sequence 1:	NP_648294.1	Gene:	CG4483 / 39057	FlyBaseID:	FBgn0035970	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001365935.1	Gene:	Zdhhc1 / 70796	MGIID:	1918046	Length:	484	Species:	Mus musculus

Alignment Length:	214	Identity:	50/214 - (23%)
Similarity:	79/214 - (36%)	Gaps:	62/214 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 HWGPITLLTL-TLIVTWTVIHMNSMWWAPGSSLESVLNYALIWIQTFGTLYNFIRSLMVGPGFVP 77
            ||.|.....: .:.....|:|:.::...|..:.....:|:       |.|..|.||
Mouse    74 HWVPAGYACMGAIFAGHLVVHLTAVSIDPADANVRDKSYS-------GPLPIFNRS--------- 122

  Fly    78 LKWHPQLTKDKMFLQFCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWINTCVGWSNQDSFVYFLL 142
              .|..:.:|    ..|..|:...:.||.||..||:||...||||.|:|.|||..|      :.|
Mouse   123 --QHAHVIED----LHCNLCDVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERN------YRL 175

  Fly   143 FFMSGSIHGGIIIVSAVIRGIKKRWLIRYGLRHMATVHLTQTNLLACVFSLGVIMGTVLASIKLL 207
            |..|         |::.:.|:                      ||..:.:..|.:...:..::|.
Mouse   176 FLHS---------VASALLGV----------------------LLLVLVATYVFVEFFVNPMRLR 209

  Fly   208 YMQMKSILKNQTEIENWIV 226
            ..|...:|||.|::  |.|
Mouse   210 TNQHFEVLKNHTDV--WFV 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4483	NP_648294.1	zf-DHHC	88..224	CDD:279823	34/135 (25%)
Zdhhc1	NP_001365935.1	Mediates interaction with STING1. /evidence=ECO:0000250\|UniProtKB:Q8WTX9	1..268		50/214 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		DHHC	126..281	CDD:396215	37/144 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..415
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000