DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4483 and Zdhhc6

DIOPT Version :9

Sequence 1:	NP_648294.1	Gene:	CG4483 / 39057	FlyBaseID:	FBgn0035970	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001028745.1	Gene:	Zdhhc6 / 66980	MGIID:	1914230	Length:	413	Species:	Mus musculus

Alignment Length:	418	Identity:	158/418 - (37%)
Similarity:	226/418 - (54%)	Gaps:	50/418 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CIKLK----DDLRRFIHWGPITLLTLTLIVTWTVIHMNSMWWAPGSSLESVLNYALIWIQTFGTL 62
            |..:|    .||||..|||||..|.:..|.:...:..:.:|:.|..:....:|:.::...|...|
Mouse     5 CSVIKFENLQDLRRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMIL 69

  Fly    63 YNFIRSLMVGPGFVPLKWHPQLTKDKMFLQFCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWINT 127
            ||:..::..||||||..|.|:.::|.|:||:|..|..||||||||||:||||||||||||||||.
Mouse    70 YNYFNAMFAGPGFVPRGWKPEKSQDSMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINN 134

  Fly   128 CVGWSNQDSFVYFLLFFMSGSIHGGIIIVSAVIRGIKKR----W----------------LIRYG 172
            |.|..|..||..|||....|..|...|.|..:...:..|    |                ::.:|
Mouse   135 CCGHQNHASFTLFLLLAPLGCTHAAFIFVMTMYTQLYNRLSFGWNTVKIDMSAARRDPPPIVPFG 199

  Fly   173 LRHMATVHLTQTNLLACVFSLGVIMGTVLASIKLLYMQMKSILKNQTEIENWIVKKAAFRRNAYP 237
            |...|          |.:|:||:.:||.:|...|.::|:|.||:|:|.||:||.:||..|...|.
Mouse   200 LAAFA----------ATLFALGLALGTTIAVGMLFFIQIKIILRNKTSIESWIEEKAKDRIQYYQ 254

  Fly   238 RKGIKPFVYPYNLG--WKTNMREVF----FSTGDGISWPVLPDCNEYSLTCEQLQQKKDKRARTR 296
            ...:  |::||::|  || |.::||    ...|||:.||:...|::||||.|||:||.|||.|:.
Mouse   255 LDEV--FIFPYDMGSKWK-NFKQVFTWSGVPEGDGLEWPIREGCDQYSLTIEQLKQKADKRVRSV 316

  Fly   297 VFRCIRPATGHWVPIFSQGLWVSLQIPCTDDPRIALKPDDIIHVTRIQEYWLYGEIMISEKQKEK 361
            .::.|....|...|: ::|:......|||::|||.|:..:.|..||...|||||:.::.:...|
Mouse   317 RYKVIEDYNGACCPL-NRGVRTFFTSPCTEEPRIRLQKGEFILATRGLRYWLYGDKILDDSFIE- 379

  Fly   362 IRARKGAIRGWFPSCCAIEICE-DSDSE 388
               ....:|||||..| :|.|. |.||:
Mouse   380 ---GTSRVRGWFPRNC-VEKCPCDGDSD 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4483	NP_648294.1	zf-DHHC	88..224	CDD:279823	64/155 (41%)
Zdhhc6	NP_001028745.1	DHHC	95..241	CDD:366691	64/155 (41%)
		SH3_2	317..396	CDD:369452	27/84 (32%)
		Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9H6R6	410..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842485
Domainoid	1	1.000	136	1.000	Domainoid score	I4898
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2602
Isobase	1	0.950	-	0	Normalized mean entropy	S2699
OMA	1	1.010	-	-		QHG52433
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	1	1.000	-	-		FOG0006604
OrthoInspector	1	1.000	-	-		otm43052
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22883
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.820