DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4483 and ZDHHC6

DIOPT Version :9

Sequence 1:	NP_648294.1	Gene:	CG4483 / 39057	FlyBaseID:	FBgn0035970	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001338011.1	Gene:	ZDHHC6 / 64429	HGNCID:	19160	Length:	413	Species:	Homo sapiens

Alignment Length:	421	Identity:	163/421 - (38%)
Similarity:	234/421 - (55%)	Gaps:	50/421 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CIKLK----DDLRRFIHWGPITLLTLTLIVTWTVIHMNSMWWAPGSSLESVLNYALIWIQTFGTL 62
            |..:|    .:|:|..|||||..|.:..|.:...:..:.:|:.|..:....:|:.::...|...|
Human     5 CSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMIL 69

  Fly    63 YNFIRSLMVGPGFVPLKWHPQLTKDKMFLQFCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWINT 127
            ||:..::.||||||||.|.|::::|.|:||:|..|..||||||||||:||||||||||||||||.
Human    70 YNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINN 134

  Fly   128 CVGWSNQDSFVYFLLFFMSGSIHGGIIIVSAVIRGIKKR----W----------------LIRYG 172
            |.|:.|..||..|||....|.||...|.|..:...:..|    |                ::.:|
Human   135 CCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFG 199

  Fly   173 LRHMATVHLTQTNLLACVFSLGVIMGTVLASIKLLYMQMKSILKNQTEIENWIVKKAAFRRNAYP 237
            |...||.          :|:||:.:||.:|...|.::|||.||:|:|.||:||.:||..|...|.
Human   200 LAAFATT----------LFALGLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQ 254

  Fly   238 RKGIKPFVYPYNLG--WKTNMREVF----FSTGDGISWPVLPDCNEYSLTCEQLQQKKDKRARTR 296
            ...:  ||:||::|  |: |.::||    ...|||:.|||...|::||||.|||:||.|||.|:.
Human   255 LDEV--FVFPYDMGSRWR-NFKQVFTWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSV 316

  Fly   297 VFRCIRPATGHWVPIFSQGLWVSLQIPCTDDPRIALKPDDIIHVTRIQEYWLYGEIMISEKQKEK 361
            .::.|...:|...|: ::|:......|||::|||.|:..:.|..||...|||||:.::.:...|.
Human   317 RYKVIEDYSGACCPL-NKGIKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEG 380

  Fly   362 IRARKGAIRGWFPSCCAIEICEDSDSENDLA 392
            :    ..||||||..| :|.| ..|:|.|.|
Human   381 V----SRIRGWFPRKC-VEKC-PCDAETDQA 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4483	NP_648294.1	zf-DHHC	88..224	CDD:279823	66/155 (43%)
ZDHHC6	NP_001338011.1	DHHC	95..241	CDD:396215	66/155 (43%)
		SH3	317..394	CDD:418401	27/82 (33%)
		Di-lysine motif. /evidence=ECO:0000269\|PubMed:21926431	410..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152419
Domainoid	1	1.000	139	1.000	Domainoid score	I4798
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2672
Isobase	1	0.950	-	0	Normalized mean entropy	S2699
OMA	1	1.010	-	-		QHG52433
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	1	1.000	-	-		FOG0006604
OrthoInspector	1	1.000	-	-		otm40981
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22883
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.820