DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4483 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_648294.1	Gene:	CG4483 / 39057	FlyBaseID:	FBgn0035970	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001034429.1	Gene:	Zdhhc17 / 366889	RGDID:	1595790	Length:	622	Species:	Rattus norvegicus

Alignment Length:	298	Identity:	73/298 - (24%)
Similarity:	106/298 - (35%)	Gaps:	80/298 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LIVTWTVIHMNSMW-WAPGSSLESVLNYALIWIQTFGTLYNFIRSLMVGPGFVPLKWHPQLTKDK 88
            :.|||      ..| |...|.|...|.:....:..|   |||.:|....||.:..   .:..|.|
  Rat   360 MYVTW------FFWFWNDLSFLSIHLPFLANSVALF---YNFGKSWKSDPGIIKA---TEEQKKK 412

  Fly    89 MFLQ-----------FCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWINTCVGWSNQDSF---VY 139
            ..::           ||:.|...|..||.||..||||:.|.||||||:..||...|...|   ::
  Rat   413 TIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVCAGNHRYFMGYLF 477

  Fly   140 FLLFFMSGSIHGGIIIVSAVIRGIKKRWLIRYGLRHMATVHLTQ------TNLLAC--------- 189
            ||||.:...|:|                .:.|...|..|.:...      |.:..|
  Rat   478 FLLFMICWMIYG----------------CVSYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFL 526

  Fly   190 --VFSLGVIMGTVLASIKLLYMQMKSILKNQTEIENWIVKKAAFRRNAYPRKGIK----PFVYPY 248
              ||..  :...||...::..:....|..|:             |.||...|..|    ....|:
  Rat   527 NSVFHF--MWVAVLLMCQMYQITCLGITTNE-------------RMNARRYKHFKVTTTSIESPF 576

  Fly   249 NLGWKTNMREVFFSTGDGISWPVLPD-CNEYSLTCEQL 285
            |.|...|:.:.|.....|:..||:.| ..:|::..:|:
  Rat   577 NHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQI 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4483	NP_648294.1	zf-DHHC	88..224	CDD:279823	41/166 (25%)
Zdhhc17	NP_001034429.1	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	1..295
		Ank_4	<60..100	CDD:290365
		ANK	77..192	CDD:238125
		ANK repeat	79..110	CDD:293786
		Ank_2	84..177	CDD:289560
		ANK repeat	112..144	CDD:293786
		ANK	143..267	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_2	151..245	CDD:289560
		ANK repeat	179..211	CDD:293786
		ANK repeat	214..245	CDD:293786
		zf-DHHC	428..558	CDD:279823	41/160 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810