DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4483 and zdhhc8b

DIOPT Version :9

Sequence 1:	NP_648294.1	Gene:	CG4483 / 39057	FlyBaseID:	FBgn0035970	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_840089.2	Gene:	zdhhc8b / 352941	ZFINID:	ZDB-GENE-030407-3	Length:	751	Species:	Danio rerio

Alignment Length:	367	Identity:	80/367 - (21%)
Similarity:	135/367 - (36%)	Gaps:	98/367 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PITLLTLTLIVTWTVIHMNSMWW-----APGSSLESVLNYALIWIQTFGTLYNFIRSLMVGPGF- 75
            |::.....|:.:.|:..:.:..|     :|...|.:.:.:..:       |.||..:..:.||.
Zfish    16 PVSTAATLLVGSTTLFFVFTCPWLTKAVSPVVPLYNGIVFLFV-------LANFSMATFMDPGVF 73

  Fly    76 --------------VPLKWHPQLTKDKMFLQFCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWIN 126
                          .||..:.::...::.:::|..|:.|:.||..||..|:.||.:.||||||:|
Zfish    74 PRADEDEDKDDDFRAPLYKNVEIKGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEEFDHHCPWVN 138

  Fly   127 TCVGWSNQDSFVYFLLFFMSGSIHGGIIIVSAVIRGIKKRWLIRYGLRHMAT---VHLTQTNLLA 188
            .|:|..|   :.||.||.:|.|:|    :|.....|      :.:.|.|:.|   :|.|.|.::.
Zfish   139 NCIGRRN---YRYFFLFLLSLSVH----MVGVFSFG------LLFMLHHLETLSALHTTVTLVVM 190

  Fly   189 CVFSLGVI--MGTVLASIKLLYMQMKSILKNQT----------------------EIENWIVKKA 229
            ||..|..|  ||       |....|..:.:.:|                      .:::.:....
Zfish   191 CVTGLFFIPVMG-------LTGFHMVLVARGRTTNEQVTGKFRGGVNPFTRGCGGNVKHVLCSPL 248

  Fly   230 AFRRNAYPRKGIKPFVYPYNLGWKTNMREVFFSTGD-GI-----------------------SWP 270
            |.|..|.|||.|...|.|..|....:.|.:.....| ||                       ..|
Zfish   249 APRYIADPRKKIPVTVTPPFLRPDLSNRHISVKVSDNGIHSNILRSKSKTSLNGMDDKSIDAQPP 313

  Fly   271 VLPDCNEYSLTCEQLQQKKDKRARTRVFRCIRPATGHWVPIF 312
            :.|..:.|:....||...::....::......||...:.|.|
Zfish   314 LPPKADRYNQIKSQLTSSEESSLSSKPTNPSTPAMFKYRPSF 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4483	NP_648294.1	zf-DHHC	88..224	CDD:279823	44/162 (27%)
zdhhc8b	NP_840089.2	zf-DHHC	99..224	CDD:279823	44/144 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..346		5/52 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..659
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..685
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810