DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4483 and ZDHHC8

DIOPT Version :9

Sequence 1:	NP_648294.1	Gene:	CG4483 / 39057	FlyBaseID:	FBgn0035970	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001171953.1	Gene:	ZDHHC8 / 29801	HGNCID:	18474	Length:	778	Species:	Homo sapiens

Alignment Length:	247	Identity:	63/247 - (25%)
Similarity:	99/247 - (40%)	Gaps:	49/247 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PITLLTLTLIVTWTVIHMNSMWWAPGSSLESVLNY-ALIWIQTFGTLYNFIRSLMVGPGFVPLKW 80
            |:......|:.:.|:..:.:..|...:...:|..| .:|::   ..|.||..:..:.||..|...
Human    16 PVATAAALLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFL---FVLANFSMATFMDPGVFPRAD 77

  Fly    81 HPQLTKD---------------KMFLQFCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWINTCVG 130
            ..:..:|               ::.:::|..|:.|:.||..||..|:.||...||||||:|.|:|
Human    78 EDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIG 142

  Fly   131 WSNQDSFVYFLLFFMSGSIHGGIIIVSAVIRGIKKRWLIRYGLRH---MATVHLTQTNLLACVFS 192
            ..|   :.||.||.:|.|.|    :|..|..|:.      |.|.|   :...|.|.|..:.||..
Human   143 RRN---YRYFFLFLLSLSAH----MVGVVAFGLV------YVLNHAEGLGAAHTTITMAVMCVAG 194

  Fly   193 LGVIMGTVLASIKLLYMQMKSILKNQTEIENWIVKKAAFRRNAYPRKGIKPF 244
            |..|     ..|.|....:..:.:.:|..|....|.         |.|:.||
Human   195 LFFI-----PVIGLTGFHVVLVTRGRTTNEQVTGKF---------RGGVNPF 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4483	NP_648294.1	zf-DHHC	88..224	CDD:279823	44/138 (32%)
ZDHHC8	NP_001171953.1	DHHC	99..224	CDD:366691	44/142 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..352
		PHA03247	<333..771	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810