Protein Alignment CG4476 and SLC6A5

DIOPT Version :10

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 222/650 - (34%)
• Similarity: 349/650 - (53%)
• Gaps: 75/650 - (11%)

  Fly     6 TEILVSGGLPKLETSRCAGSGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVG 70
            |.:|.:.|:            .::|..|:..:|.:..|...:.|||.||.|.|:|::|.:..:||
Human   158 TVVLATDGI------------TSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVG 210

  Fly    71 LGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYA 135
            ||||||||:.|.:|||||||||||::|.:.|.||:::|:.||||:|:|.|.|:...|.::|.|.|
Human   211 LGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIA 275

  Fly   136 QLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG------------DGCVSASGGQPL 188
            .|:...::|.||..::..||.|.|.||.|.|||..|...|.            |.|| .|....:
Human   276 MLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCV-ISDHPKI 339

  Fly   189 Q--------------------GQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPS---GSLALML 230
            |                    .|.::.|.|.::.|.:..||    .:..||.||.   ..|||.|
Human   340 QIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVL----KISAGIEYPGEIRWPLALCL 400

  Fly   231 GISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQ 295
            .::|:.|...:.:|:|:|||..|..|.|||||:.|||:|.:|||||..|:.||:||:||||.:..
Human   401 FLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDAT 465

  Fly   296 VWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHE 360
            ||.:|.||:||||:..:|.:|..||||:|.:|.|||..|||..::.||:.:|.:||.::|.:|:|
Human   466 VWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANE 530

  Fly   361 SGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQ 425
            ... :|.:|...|||:||:.||:|:.:..:.| .::::||.||..||:.:....:..|:|.:.|:
Human   531 RKV-NIENVADQGPGIAFVVYPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDE 593

  Fly   426 F---VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGT 487
            |   :.....:..:...:..|::|...||.||.::..|:|.:..::..::.|||||:.:.::||.
Human   594 FPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGL 658

  Fly   488 KRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSG 552
            :|.|:|.|.|:..:.:.::::||:.|||.::..||.:|.....|::|....:|....|:||.:..
Human   659 QRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLA 723

  Fly   553 CIIGQLFYWAG---YANFKQPKGSLKSRINNSIKPHSDWGPSDPKKLMDYQMFLRNKDEENSKNV 614
            |.:    .|..   ........|....|:.....|..||||           ||.....|..||:
Human   724 CSV----IWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGP-----------FLAQHRGERYKNM 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	191/511 (37%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	213/604 (35%)