DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and Slc6a2

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_112633.2	Gene:	Slc6a2 / 83511	RGDID:	621822	Length:	617	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	205/562 - (36%)
Similarity:	316/562 - (56%)	Gaps:	37/562 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLL 111
            |.:.|:.||..::||:|.:..:|.|.||||||:...:||||||||||.:.|.:.|.|::|||:.|
  Rat    52 DAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELAL 116

  Fly   112 GQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG 176
            |||:..|...|:...|..:|||||.:|....:..||..::|.:|.|.|.||...|||:.|...|.
  Rat   117 GQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWN 181

  Fly   177 D-GC-----VSASGGQPLQGQLSR----NFSSSTQLYLQRIV-LNETDSLEEGIGYPSGSLALML 230
            . .|     ::||    :.|..::    .|:.:.:.|.:.:: |:|:..:.: ||.|...|.|.|
  Rat   182 SPNCTDPKLLNAS----VLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHD-IGLPQWQLLLCL 241

  Fly   231 GISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQ 295
            .:..:.:...:.:|||:|||..::.|..||.|:|:|||..:|||||.:|:..:|...:.:|.|..
  Rat   242 MVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEAT 306

  Fly   296 VWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHE 360
            ||.:|.||:||||...|||:|.::|||:|.:|.||||.:.:|::..||.:||..||.|||.:|||
  Rat   307 VWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHE 371

  Fly   361 SGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQ 425
            ...| |..|...|.||.|:.||:||:... ....:::|||.||..||:.|::|.:..::|.|.|.
  Rat   372 HKVK-IEDVATEGAGLVFVLYPEAISTLS-GSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADD 434

  Fly   426 FV----NVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIF----ELIAVG 482
            |.    :.||:...|:|..  ||:.:..||.||.:::||:|    ||.:..|.:|    |.|.|.
  Rat   435 FQVLKRHRKLFTCAVTLGT--FLLAMFCITKGGIYVLTLLD----TFAAGTSILFAVLMEAIGVS 493

  Fly   483 WIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVG 547
            |.||..|...|.:.|:..|...|:|:||..|:|..:|.::|.|::..:||:|:...:|.....||
  Rat   494 WFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVG 558

  Fly   548 WCVSGCIIGQLFYWAGYANFK--QPKGSLKSRINNSIKPHSD 587
            |   |..:..:.....|..:|  ..:|||..|:...|.|.::
  Rat   559 W---GIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENE 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	186/492 (38%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:382020	204/558 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820