DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and zgc:158427

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_017207457.1	Gene:	zgc:158427 / 790932	ZFINID:	ZDB-GENE-061215-110	Length:	579	Species:	Danio rerio

Alignment Length:	557	Identity:	200/557 - (35%)
Similarity:	314/557 - (56%)	Gaps:	30/557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |..||...|||::.....||||||||||:....||||.|||||||.:...|.|::.:|..:|||:
Zfish    11 RGFWGKKTEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGVPLFLLETAMGQFT 75

  Fly   116 SRGIVQVFD-FAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DG 178
            ..|.:..:. ..||.:|:|||..|.:.....|:..::|..|.|...||:|:|||:.|...|. |.
Zfish    76 HEGGITCWHRLCPLAQGIGYAGQLTVLYSCMYFTIILAWALFYLISSFSSQLPWASCDNIWNTDN 140

  Fly   179 CVSASGGQPLQGQLSRNFSSSTQL----------YLQRIVLNETDSLEEGIGYPSGSLALMLGIS 233
            ||:.:.|       :..|:.:||:          :.:|.||:.:..:|: ||..:..:.|.|...
Zfish   141 CVNLAAG-------NLTFNRTTQMLINSTSAATEFWERRVLSLSGGIED-IGKINWEILLCLIAM 197

  Fly   234 WLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWY 298
            |:.....|.:||||:||..|..|.||||::.:||:|.||||||..|::::|.|:..:|.:||||.
Zfish   198 WIICYFCIWKGVKSTGKVVYFTATFPYVMLIVLLIRGLTLPGALQGIVFYLYPEPARLADPQVWM 262

  Fly   299 NAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGT 363
            .|.||:|||.:|..||:|...|||::.:|.|||...:..|::.||.::|..:|.:||.:||..|.
Zfish   263 EAGTQIFFSYSVIGGVLISLGSYNQYNNNCYRDCFWLCLLNSGTSFVAGFAVFSVLGFMAHVQGV 327

  Fly   364 KDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVN 428
             .|..|.::|||||||:||.|:|... |||::::.||.|:.:||:.:....|.|::|.:.|.|..
Zfish   328 -PIEEVAESGPGLAFIAYPQAVAMMP-FPQLWAVCFFIMIILLGLDTQFVSVECVITSVMDLFPE 390

  Fly   429 V-----KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGT 487
            |     :..::|:.|.:..|...||.:|.||.::..|.|.:......|: .::||.:|:|||:|.
Zfish   391 VLRRAGRRELLVLLLCLTCFFGQLIMVTEGGMYVFQLFDNYACNGACLLFLSVFESLAIGWIFGA 455

  Fly   488 KRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYN-GQEFPLVYRVVGWCVS 551
            :::....|.|...:.:.::.:||..:||||.|...|||::...||::| ...:|....|:||.::
Zfish   456 EKMFDIIEDMTESRPNYWFMLCWKYLTPLVSLTSFVYSMVRYTPLTFNRWYIYPDWAYVLGWLLA 520

  Fly   552 GCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDW 588
            ...|..:..|| .......|||||.|..:...|.:::
Zfish   521 LSSILLVPAWA-LGQMCAGKGSLKQRWRHLSSPETNF 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	181/491 (37%)
zgc:158427	XP_017207457.1	SLC6sbd-TauT-like	11..552	CDD:271387	199/551 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820