DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and slc6a1a

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001038752.2	Gene:	slc6a1a / 692318	ZFINID:	ZDB-GENE-060519-23	Length:	679	Species:	Danio rerio

Alignment Length:	554	Identity:	202/554 - (36%)
Similarity:	323/554 - (58%)	Gaps:	37/554 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEML 110
            ||   |:.||...:||:||:..::|||||||||:...:||||||||||.:.|...|.|::::|..
Zfish    41 PD---RETWGGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFFLECA 102

  Fly   111 LGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEW 175
            |||::|.|.:.|:..||:.:|||.|..:....|..||..::|..|.|.::||.::|||..|...|
Zfish   103 LGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIAWALYYLYNSFTTDLPWKSCNNPW 167

  Fly   176 G-DGC------VSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEE--GIGYPSGSLALMLG 231
            . |.|      |..:           |.:|:...:.:|.|...||.||:  .|..|   ||:.|.
Zfish   168 NTDRCYTNYSIVDTT-----------NLTSAVMEFWERNVHQMTDGLEKPGEIRVP---LAITLA 218

  Fly   232 ISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQV 296
            |:|:.|...|.:||..:||..|..|.:||.::|||.:|.:|||||.:|:::::||.:|||.|.:|
Zfish   219 IAWVLVYFCIWKGVSWTGKVVYFSATYPYFMLFILFIRGVTLPGAKEGILFYITPDFEKLKESEV 283

  Fly   297 WYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHES 361
            |.:|.||:|||..:..|.:|...|||.|.:|||||:.||..:::|||:.:|.:||.|:|.::|.:
Zfish   284 WLDAATQIFFSYGLGLGSLIALGSYNPFNNNVYRDSIIVCCINSFTSMFAGFVIFSIVGFMSHVT 348

  Fly   362 GTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQF 426
             .:.||.|..:||||||::||:|:.:..:.| ::::|||:||.|||:.|....|...:|.|.|:|
Zfish   349 -KRPIADVAASGPGLAFLAYPEAVTQLPVSP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEF 411

  Fly   427 ---VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAI-FELIAVGWIYGT 487
               :..:..|.:..:.|:.:.:||..||.||.::..|.|::..:.:.|:..: ||.|::.|.||.
Zfish   412 PRLLRKRREIFIACVCVVSYAIGLSNITQGGLYVFKLFDYYSASGMCLLFLVFFECISISWCYGV 476

  Fly   488 KRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSG 552
            .:...:.:.|:..|...::::||...||||:..:.::|.:.|.||:.|...||...:.|||.::
Zfish   477 NKFYDNIQEMIGYKPCIWWKLCWVFFTPLVVAGVFLFSAVQMVPLTMNNYVFPKWGQGVGWLMA- 540

  Fly   553 CIIGQLFYWAGYAN--FKQPKGSLKSRINNSIKP 584
              :..:....||..  |...||:.|.||...::|
Zfish   541 --LSSMVLIPGYMGYMFLNLKGTYKERIRIMLQP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	180/486 (37%)
slc6a1a	NP_001038752.2	SLC5-6-like_sbd	2..588	CDD:294310	202/554 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920