Protein Alignment CG4476 and SLC6A12

DIOPT Version :9

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001116319.1
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 201/588 - (34%)
• Similarity: 321/588 - (54%)
• Gaps: 59/588 - (10%)

  Fly    49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQ 113
            |.|..|.:.:||::|.....:|||||||||:...:||||||.|||.:..||.|.|::::|:.|||
Human    34 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQ 98

  Fly   114 FSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEW-- 175
            ::|:|.|..: ...||.:|:|.|.::....|..||..::|..|.|.|.||.|||||:.|...|
Human    99 YTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNT 163

  Fly   176 ----------GDGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALML 230
                      |.|.|:     |.:     ||:|....:.:|.||..|..:.: :|.....|||.|
Human   164 EHCTDFLNHSGAGTVT-----PFE-----NFTSPVMEFWERRVLGITSGIHD-LGSLRWELALCL 217

  Fly   231 GISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQ 295
            .::|:.....|.:||||:||..|..|.|||:::.|||:|.:||||||.|::|:|.|...:|.:||
Human   218 LLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQ 282

  Fly   296 VWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHE 360
            ||.:|.||:|||.|:|.|.:....|||::.:|.|:|...:..|::.||.::|.::|.|||.::.|
Human   283 VWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQE 347

  Fly   361 SGTKDIASVVKAGPGLAFISYPDAIAKFKMFP--QVFSLLFFAMLFMLGVGSNVGMVSCIMTVLK 423
            .|. .|:.|.::|||||||::|.|:.   |.|  |::|.|||.||..||:.|....|.|::|...
Human   348 QGV-PISEVAESGPGLAFIAFPKAVT---MMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASI 408

  Fly   424 DQF-----VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVG 482
            |.|     .:.:..:::::::|:.:|:||..:|.||.:|..|.|::..:.:.|: .::||::.:.
Human   409 DMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCIS 473

  Fly   483 WIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNG-QEFPLVYRVV 546
            |:||..|...:.|.|:..:.....:|.|..:||.:.|...::||....||.||. ..:|.....:
Human   474 WVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSI 538

  Fly   547 GW--CVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHS-----------------DWGPSD 592
            ||  .:|..:...||.   .....:.:|..:.|:...|.|.|                 ::|||.
Human   539 GWFLALSSMVCVPLFV---VITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP 600

  Fly   593 PKK 595
            .::
Human   601 TRE 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	179/494 (36%)
SLC6A12	NP_001116319.1	SLC6sbd_BGT1	35..575	CDD:212080	195/557 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820