DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and SLC6A8

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_005620.1	Gene:	SLC6A8 / 6535	HGNCID:	11055	Length:	635	Species:	Homo sapiens

Alignment Length:	571	Identity:	198/571 - (34%)
Similarity:	305/571 - (53%)	Gaps:	54/571 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |:.|...::|:|||:..:||||||||||:...:||||.|||||:::..|.|.||:::|:.||||.
Human    52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFM 116

  Fly   116 SRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG---- 176
            ..|.:.|::..||.:|:|||.::.:....|||..|:|....|...||.:.|||:.|...|.
Human   117 KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDC 181

  Fly   177 ------DGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSG---SLALMLGI 232
                  :.|.:||.......||:...|...:.:..:::     .|..|:..|..   .:.|.|..
Human   182 VEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVL-----RLSGGLEVPGALNWEVTLCLLA 241

  Fly   233 SWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVW 297
            .|:.|...:.:||||:||..|..|.|||||:.:||||.:.||||.||::|:|.|.|.||..||||
Human   242 CWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVW 306

  Fly   298 YNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESG 362
            .:|.||:|||.|:..|.:....|||||.:|.|:||.|:..:::.||..:|.::|.|||.:|.|.|
Human   307 IDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQG 371

  Fly   363 TKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKD--- 424
            . .|:.|.::|||||||:||.|:....:.| :::.|||.||.:||:.|....|...:|.|.|
Human   372 V-HISKVAESGPGLAFIAYPRAVTLMPVAP-LWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLP 434

  Fly   425 --QFVNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYG 486
              .:...:..|.|.....:.|::.|..:|.||.::..|.|::..:..:|: .|.:|.:.|.|:||
Human   435 ASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYG 499

  Fly   487 TKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNG-QEFPLVYRVVGW-- 548
            ..|...|...|:..:...:.:.|||..||||.:.|.:::::...||.||. ..:|.....:||
Human   500 ADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAF 564

  Fly   549 ------CVS----GCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWG 589
                  ||.    ||::             :.||::..|..:..:|  .||
Human   565 ALSSMLCVPLHLLGCLL-------------RAKGTMAERWQHLTQP--IWG 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	180/492 (37%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
SLC6A8	NP_005620.1	SLC6sbd_CT1	52..621	CDD:271397	198/571 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820