DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and SLC6A6

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001127839.2	Gene:	SLC6A6 / 6533	HGNCID:	11052	Length:	721	Species:	Homo sapiens

Alignment Length:	581	Identity:	206/581 - (35%)
Similarity:	315/581 - (54%)	Gaps:	40/581 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLKPS--LLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLI 91
            :||||  ..|......|.......|:.|.|.::|::|.....||||||||||:...:||||||||
Human   118 ILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLI 182

  Fly    92 PYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLMRGVGYAQLLALGVLATYYASVMALTL 155
            ||.:.||..|.|::::|:::||::|.|.:..:: ..||..|:|||.::.:.:|..||..::|...
Human   183 PYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWAT 247

  Fly   156 RYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQL---SRNFSSSTQLYLQRIVLNETDSLE 216
            .|.|.||..||||:.|...|. ..|:..:..:.....:   |.||:|....:.:|.||    ||.
Human   248 YYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVL----SLS 308

  Fly   217 EGIGYPSG---SLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYD 278
            .||.:|..   .|||.|.:.||.....|.:||:|:||..|..|.||:.::.:||||.||||||..
Human   309 PGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGA 373

  Fly   279 GVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTS 343
            |:.::|.|...:|.:||||.:|.||:|||.|:|.|.:....|||::.:|.|||..::..|::.||
Human   374 GIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTS 438

  Fly   344 LLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGV 408
            .:||..||.|||.:|.|.|. |||.|.::|||||||:||.|:....: |..:|:|||.||.:||:
Human   439 FVSGFAIFSILGFMAQEQGV-DIADVAESGPGLAFIAYPKAVTMMPL-PTFWSILFFIMLLLLGL 501

  Fly   409 GSNVGMVSCIMTVLKDQFVN-----VKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTF 468
            .|....|...:|.|.|.:.:     .:..|.:..:..|.:|:||..:|.||.::..|.|::..:.
Human   502 DSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASG 566

  Fly   469 VSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPL 532
            |.|: .|.||...:.||||...|....|.|:..:...:.:..|:::||::.:...::||:...||
Human   567 VCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPL 631

  Fly   533 SYN-GQEFPLVYRVVGW--------CVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKP 584
            :|| ...:|.....:||        ||...|:.:|.         |.:|....|:...:.|
Human   632 TYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLC---------QTEGPFLVRVKYLLTP 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	182/487 (37%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	199/555 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820