Protein Alignment CG4476 and SLC6A3

DIOPT Version :10

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 210/624 - (33%)
• Similarity: 337/624 - (54%)
• Gaps: 61/624 - (9%)

  Fly    17 LETSRCA-GSGEALLKPSLLPMA------------------LESSELSPDRKA------RDNWGS 56
            :..|:|: |...:::.|:..|.|                  |.||.|:..|::      |:.||.
Human     1 MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGK 65

  Fly    57 SLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQ 121
            .::||:|.|..:|.|.||||||:...:|||||||:|||:.:.:.|.|::|||:.||||:..|...
Human    66 KIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAG 130

  Fly   122 VFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEW----------G 176
            |:...|:::|||:..:|....:..:|..::|..|.|.|.||.:||||..|...|          |
Human   131 VWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPG 195

  Fly   177 DGCVSASGGQPLQGQLSRNFSSSTQL-YLQRIV--LNETDSLEEGIGYPSGSLALMLGISWLTVT 238
            |....:||       |:..|.::... |.:|.|  |:::..::: :|.|...|...|.:..:.:.
Human   196 DSSGDSSG-------LNDTFGTTPAAEYFERGVLHLHQSHGIDD-LGPPRWQLTACLVLVIVLLY 252

  Fly   239 LIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQ 303
            ..:.:|||:|||..::.|..||||:..||:|.:|||||.||:..:|:..:.:|.|..||.:|.||
Human   253 FSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQ 317

  Fly   304 VFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIAS 368
            |.|||.|.|||:|.:||||:|.:|.||||.:.|::::.||..||.::|..||.:|.:... .|..
Human   318 VCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSV-PIGD 381

  Fly   369 VVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFV----NV 429
            |.|.||||.||.||:|||...: ...::::||.||..||:.|.:|.:..::|.|.|:|.    :.
Human   382 VAKDGPGLIFIIYPEAIATLPL-SSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHR 445

  Fly   430 KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDA 494
            :|:.:.:.|:.  ||:.|..:|.||.::.||:|........|...:.|.|.|.|.||..:...|.
Human   446 ELFTLFIVLAT--FLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDI 508

  Fly   495 EYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLF 559
            :.|...:.|.|:|:||.:|:|..:|.::|.|::|.||..|....||.....:||.::...:..:.
Human   509 QQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVP 573

  Fly   560 YWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDPKKLMD 598
            .:|.| .|....||.:.::..:|.|..|      ::|:|
Human   574 IYAAY-KFCSLPGSFREKLAYAIAPEKD------RELVD 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	179/490 (37%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	199/565 (35%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		7/29 (24%)