Protein Alignment CG4476 and SLC6A1

DIOPT Version :9

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 205/599 - (34%)
• Similarity: 340/599 - (56%)
• Gaps: 32/599 - (5%)

  Fly    10 VSGGLPKLETSRCAGSGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNV 74
            |:.|....|.|....:.:   ||..|.:.::..  :.|...||.|....:|||||:..::|||||
Human     8 VADGQISTEVSEAPVAND---KPKTLVVKVQKK--AADLPDRDTWKGRFDFLMSCVGYAIGLGNV 67

  Fly    75 WRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLA 139
            ||||:...:||||||||||.:.|...|.|::.:|..|||::|.|.:.|:..||:.:|||.|..:.
Human    68 WRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVL 132

  Fly   140 LGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSRNFSSSTQLY 203
            ...|..||..:::..:.|.::||.:.|||..|...|. |.|.|     ......:.|.:|:...:
Human   133 SFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFS-----NYSMVNTTNMTSAVVEF 192

  Fly   204 LQRIVLNETDSLEE--GIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFIL 266
            .:|.:...||.|::  .|.:|   ||:.|.|:|:.|...|.:||..:||..|..|.:||:::.||
Human   193 WERNMHQMTDGLDKPGQIRWP---LAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIIL 254

  Fly   267 LVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRD 331
            ..|.:|||||.:|:::::||.:.||.:.:||.:|.||:|||..:..|.:|...|||.|.:|||||
Human   255 FFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRD 319

  Fly   332 ANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFS 396
            :.||..:::.||:.:|.:||.|:|.:||.: .:.||.|..:||||||::||:|:.:..:.| :::
Human   320 SIIVCCINSCTSMFAGFVIFSIVGFMAHVT-KRSIADVAASGPGLAFLAYPEAVTQLPISP-LWA 382

  Fly   397 LLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV---KLWIIVVSLSVIGFLVGLIYITPGGQHII 458
            :|||:||.|||:.|....|...:|.|.|::..:   :..:.:.::.:|.:|:||..||.||.::.
Human   383 ILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVF 447

  Fly   459 TLMDFHGVTFVSLVSAI-FELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVIL 522
            .|.|::..:.:||:..: ||.:::.|.||..|...:.:.|:..:...::::|||..||:::..:.
Human   448 KLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVF 512

  Fly   523 VYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYA--NFKQPKGSLKSRINNSIKPH 585
            ::|.:.|.||:.....||...:.|||.::   :..:....||.  .|...|||||.||...::|.
Human   513 IFSAVQMTPLTMGNYVFPKWGQGVGWLMA---LSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPS 574

  Fly   586 SDW-----GPSDPK 594
            .|.     ||..|:
Human   575 EDIVRPENGPEQPQ 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	172/480 (36%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	205/599 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		3/12 (25%)
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820