DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and Slc6a17

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001028251.1	Gene:	Slc6a17 / 613226	RGDID:	1587185	Length:	727	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	189/581 - (32%)
Similarity:	308/581 - (53%)	Gaps:	91/581 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KPSLLPMALES------SELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAF 89
            |.|:|.:|.|:      :|...|.:.|..|.|.|:::::.|..||||||:||||:...:|||||:
  Rat    34 KQSVLNVAGETGGKQKVAEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAY 98

  Fly    90 LIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDF-APLMRGVGYAQLLALGVLATYYASVMAL 153
            |:||||:|.::|.|::::|:.:||...||.:.|:.: .|.:.|:|::..:....:..||..::..
  Rat    99 LVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGW 163

  Fly   154 TLRYFFDSFASELPWSFC---REEWGDGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSL 215
            ::.|||.||...||||.|   |    :|.|:.     ::.:..:  ||:|..:..|..|:.::|:
  Rat   164 SVFYFFKSFQYPLPWSECPVIR----NGTVAV-----VEPECEK--SSATTYFWYREALDISNSI 217

  Fly   216 EEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGV 280
            .|..|. :..:.:.|.::|..|.:.:::|::||||..|..:||||||:...|||.|.|.||.||:
  Rat   218 SESGGL-NWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGI 281

  Fly   281 MYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLL 345
            ::..||:.:|:|:||||..|.|||||:|.:.||.:|.:||||:..:|.:.||.:|:.::.|||:|
  Rat   282 LHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVL 346

  Fly   346 SGVIIFGILG------------------------------------NLAHESGTKDIASVVKA-- 372
            :.:::|.:||                                    |.:|.: |||.:.:...
  Rat   347 ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLT-TKDYSEMYNVIM 410

  Fly   373 --------------------------GPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSN 411
                                      |.|||||::.:|:..|...| .:|::||.||..||:||.
  Rat   411 TVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASP-FWSVMFFLMLINLGLGSM 474

  Fly   412 VGMVSCIMTVLKDQFVNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIF 476
            :|.::.|.|.:.|.| .|...:..|...|..|.|||:::...|.:.:|:.|.:..|....|..|.
  Rat   475 IGTMAGITTPIIDTF-KVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSATLPLTVIVIL 538

  Fly   477 ELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL--LTMRPLSYN 535
            |.|||.||||||:..|:...||..:...:|...|..|:||.|.|:...|:  |.:.|..|:
  Rat   539 ENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	177/541 (33%)
Slc6a17	NP_001028251.1	SLC6sbd_NTT4	60..648	CDD:271403	182/555 (33%)
Slc6a17	NP_001028251.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820