DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and slc6a6b

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	604	Identity:	214/604 - (35%)
Similarity:	328/604 - (54%)	Gaps:	57/604 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLKPS--LLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLI 91
            :||||  ..|......|.......|:.|.|.|:||:|.....||||||||||:...:||||||||
Zfish    17 ILKPSPGKSPGTRPEDEAEGKHPQREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLI 81

  Fly    92 PYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLMRGVGYAQLLALGVLATYYASVMALTL 155
            ||.:.||..|.|::::|:.||||:|.|.:..:: ..|:..|:|||.::.:.:|..||..::|..|
Zfish    82 PYFIFLFGGGLPVFFLEVALGQFTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGL 146

  Fly   156 RYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSR-----------NFSSSTQLYLQRIV 208
            .|.|..|..||||:.|..:|. :.||        :..|.|           ||:|....:.:|.|
Zfish   147 YYLFQCFQPELPWASCNNKWNTENCV--------EDTLRRNKTLWAAANATNFTSPVTEFWERNV 203

  Fly   209 LNETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTL 273
            |:.:|.:|| :|:....|||.|...|:.....:.:||||:||..||.|.||:|::.:||||.:||
Zfish   204 LSISDGIEE-VGHVKWDLALCLLAMWVICFFCVWKGVKSTGKVVYVTATFPFVMLIVLLVRGVTL 267

  Fly   274 PGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTL 338
            |||.:|:.::|.|...:|.:|:||.:|.||:|||.|:|.|.:....|||::.:|.|||..::..|
Zfish   268 PGAAEGIKFYLYPNVTRLGDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGGL 332

  Fly   339 DTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAML 403
            ::.||.:||..||.:||.:|.|.|. |||.|.::|||||||:||.|:....: |..:::|||.||
Zfish   333 NSATSFVSGFAIFSVLGFMAQEQGV-DIADVAESGPGLAFIAYPKAVTMMPL-PTFWAILFFIML 395

  Fly   404 FMLGVGSNVGMVSCIMTVLKDQFVNV-------KLWIIVVSLSVIGFLVGLIYITPGGQHIITLM 461
            .:||:.|....|...:|.|.|.:.:.       :::|.:|..  :.:|:||..:|.||.::..|.
Zfish   396 LLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCF--VSYLLGLTMVTEGGMYVFQLF 458

  Fly   462 DFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYS 525
            |::..:.|.|: .|.||.|||.|:||........|.|:..:.:.:.:..|::|||.:.:...::|
Zfish   459 DYYAASGVCLLWVAFFECIAVAWVYGADNFYDAIEEMIGYRPNPWMKWSWTVVTPFLCVGCFIFS 523

  Fly   526 LLTMRPLSYNG-QEFPLVYRVVGW--------CVSGCIIGQLFYWAGYANFKQPKGSLKSRINNS 581
            |:...||.||. .|:|.....|||        |:...::.::.         |..|.|..||...
Zfish   524 LVKYAPLRYNKIYEYPDWSIGVGWTLALASMICIPMVVVIKII---------QSDGPLIERIKAV 579

  Fly   582 IKPHSDWGPSDPKKLMDYQ 600
            ..|......|.|:   :||
Zfish   580 AAPVRGGASSCPQ---EYQ 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	185/494 (37%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	203/562 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920