DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and slc6a1l

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_021330952.1	Gene:	slc6a1l / 568985	ZFINID:	ZDB-GENE-041210-296	Length:	578	Species:	Danio rerio

Alignment Length:	557	Identity:	200/557 - (35%)
Similarity:	320/557 - (57%)	Gaps:	31/557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPI 104
            |.....||   |.:|....:||:||:..::|||||||||:...:||||||||||...|...|.|:
Zfish    19 EKENKIPD---RGSWKGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFTTLVFAGIPL 80

  Fly   105 YYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWS 169
            :.:|..|||::|.|.:.|:...|:|:|||.|.::....|..||..::|..|.|.|.|..:||||.
Zfish    81 FLLETALGQYTSVGGLGVWKLIPMMKGVGLAAVVLSFWLNIYYIIIIAWALYYLFSSLKAELPWQ 145

  Fly   170 FCREEWG-DGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEE--GIGYP-SGSLALML 230
            .|...|. |.|.|   ...|..  :.|.||:...:.:|.:...|:.|||  .:.:| .|:|||
Zfish   146 TCDNPWNTDRCFS---NYSLLD--TTNLSSAVTEFWERNMHQLTNGLEEPGELRWPLVGTLAL-- 203

  Fly   231 GISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQ 295
              ||:.|...|.:||:.:||..|..|.:||.::|||..|.:|||||.|||::::||.:.|||:.:
Zfish   204 --SWILVYFSIWKGVEWTGKVVYFSATYPYFMLFILFFRGVTLPGAIDGVLFYITPNFNKLLKSE 266

  Fly   296 VWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHE 360
            ||.:|.||:|||..:..|.:|...|||.|.:|||||:.||..:::.||:.:|::||.|:|.:::.
Zfish   267 VWLDAATQIFFSYGLGLGSLIALGSYNSFNNNVYRDSVIVCCINSCTSMFAGIVIFSIVGFMSYI 331

  Fly   361 SGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQ 425
            : .:.|..:..:||||||::||.|:.:..| ..::::|||:||.|||:.|....|...:|.|.|:
Zfish   332 T-KRPIEELAASGPGLAFLAYPQAVTQLPM-SSLWAILFFSMLMMLGLDSQFCTVEGFITALMDE 394

  Fly   426 FVNV-----KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAI-FELIAVGWI 484
            :..|     |::|::|.|  :.|::|...||.||.::..|.|::..:.:.|:..: ||.|::.|.
Zfish   395 YPTVLRKRKKIFILIVCL--VSFIIGFSNITQGGLYVFKLFDYYSASGMCLLFLVFFETISIAWF 457

  Fly   485 YGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWC 549
            ||.::..::.|.|:..:...:::.||...||.:.|.:..:|.:.|.||:.....:|...:.|||.
Zfish   458 YGAEKFYKNIEEMIGYRPCGFWKQCWIYFTPTICLGVFTFSAIEMTPLTLGKYVYPAWGQGVGWL 522

  Fly   550 VSGCIIGQLFYWAGYA--NFKQPKGSLKSRINNSIKP 584
            :|   :..:....||.  .|...||:::.|.:...||
Zfish   523 MS---LSSMVLIPGYIIYMFFSTKGNIRQRWHKMTKP 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	179/483 (37%)
slc6a1l	XP_021330952.1	SLC5-6-like_sbd	15..558	CDD:320982	200/557 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820