DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and slc6a8

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	586	Identity:	221/586 - (37%)
Similarity:	330/586 - (56%)	Gaps:	43/586 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PMALESSELSPDRK------ARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYL 94
            ||:..:..:|...|      .|:.|...::|:|||:..:||||||||||:...:||||.|||||:
Zfish    43 PMSAATGAISAVEKKREGYPERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYV 107

  Fly    95 VVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFF 159
            :.:|:.|.||:::|:.||||...|.:.|::.|||.:|:|||.::.:....|||..|:|....||.
Zfish   108 LFIFLGGIPIFFLEIALGQFMKAGSINVWNIAPLFKGLGYASMVIVFFCNTYYIMVLAWGFYYFI 172

  Fly   160 DSFASELPWSFCREEW-----------GDGCVSASGGQPLQGQLS----RNFSSSTQLYLQRIVL 209
            .||.:.||||.|...|           || |.:.:.|....|.|:    .|..|....:.:..||
Zfish   173 KSFNATLPWSTCDNPWNTENCIEIFRQGD-CKNGTIGNSTFGNLTCEELANGRSPIIEFWENKVL 236

  Fly   210 NETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLP 274
            |.:|.|:|. |..:..|.|.|...|:.|...:.:||||:||..|..|.|||||:.|||||.:|||
Zfish   237 NISDGLDEP-GAVNWELMLCLLAVWVMVYFCVWKGVKSTGKIVYFTATFPYVVLIILLVRGVTLP 300

  Fly   275 GAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLD 339
            |||||::|::.|.|.||.|.|||.:|.||:|||.|:..|.:....|||||.::.|:||.::..::
Zfish   301 GAYDGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLALIN 365

  Fly   340 TFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLF 404
            :.||..:|.::|.|||.:|.|.|. ||:.|.::|||||||:||.|::...:.| |::.|||.||.
Zfish   366 SGTSFFAGFVVFSILGFMASEQGV-DISKVAESGPGLAFIAYPKAVSMMPVAP-VWAALFFIMLL 428

  Fly   405 MLGVGSNVGMVSCIMTVLKDQF-----VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFH 464
            :||:.|....|...:|.:.|.|     :..:..|.|....::.|::.|..:|.||.::..|.|::
Zfish   429 LLGLDSQFVGVEGFVTGILDLFPGKYYMRYQREIAVAICCLLCFIIDLSMVTQGGMYVFQLFDYY 493

  Fly   465 GVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLT 528
            ..:.::|: .|.:|.:.|.|:||..|...|...|:..:...:.:.||||:||.|.:.|.::.||.
Zfish   494 SASGMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPFPWMKWCWSIITPCVCMGIFLFHLLN 558

  Fly   529 MRPLSYNG-QEFPLVYRVVGWCVS----GCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDW 588
            .:||:||. ..:|....|:|||::    .||...|.|     .....||:.|.|..|..||  .|
Zfish   559 YKPLTYNNVYVYPWWGEVIGWCLALSSMLCIPVSLVY-----KLSGAKGTFKERWENLTKP--VW 616

  Fly   589 G 589
            |
Zfish   617 G 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	192/494 (39%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	217/565 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820