DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and si:ch211-132b12.6

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001038523.1	Gene:	si:ch211-132b12.6 / 564583	ZFINID:	ZDB-GENE-050420-179	Length:	577	Species:	Danio rerio

Alignment Length:	570	Identity:	209/570 - (36%)
Similarity:	323/570 - (56%)	Gaps:	48/570 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |..||...|||::.....||||||||||:....||||.|||||||.:...|.|::.:|..:|||:
Zfish    11 RGFWGKKAEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGLPLFLLETAMGQFT 75

  Fly   116 SRGIVQVFD-FAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DG 178
            ..|.:..:. ..||.:|||||..|.:.....||..::|..|.|...||:|:|||..|...|. |.
Zfish    76 HEGGITCWHRLCPLAQGVGYAGQLTVLYSCMYYTIILAWALFYLVSSFSSQLPWVSCNNIWNTDN 140

  Fly   179 CVSASGGQPL--QGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALMLGISWLTVTLII 241
            ||:.:.|...  :..|:.:.|::|:.: :|.||:.:..:|: ||..:..:.|.|...|:.....|
Zfish   141 CVNLAAGNLTFNRTTLANSTSAATEFW-ERRVLSLSGGIED-IGKINWEILLCLIAMWIICYFCI 203

  Fly   242 IRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFF 306
            .:||||:||..|..|.||||::.:||:|.||||||..||:::|.|:..:|.:||||..|.|||||
Zfish   204 WKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWMEAGTQVFF 268

  Fly   307 SLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVK 371
            |.:||.|::|...|||::.:|.|||:..:..|::.||.::|..:|.:||.:||..|. .:..|.:
Zfish   269 SYSVCSGILISLGSYNQYSNNCYRDSFWLCLLNSGTSFVAGFAVFSVLGFMAHVQGV-PVEEVAE 332

  Fly   372 AGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV------- 429
            :|||||||:||.|:|... |||::::.||.|:.:||:.|....:.|::|.:.|.|..|
Zfish   333 SGPGLAFIAYPQAMAMMP-FPQLWAVCFFIMIILLGLDSQFVGIECVITSVMDLFPEVLRRAGRR 396

  Fly   430 KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQD 493
            :|:::::.|:.  |...||.:|.||.::..|.|.:......|: .::||.:|:||::|.:::...
Zfish   397 ELFVLLLCLTC--FFGQLIMVTEGGMYVFQLFDNYACNGACLLFLSVFESLAIGWLFGAEKMFDI 459

  Fly   494 AEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYN-GQEFPLVYRVVGW--------C 549
            .|.|...:.:.::.:||..:||||.|:..|||::...||::| ...:|.....:||        .
Zfish   460 IEDMTESRPNYWFMLCWKYLTPLVSLMSFVYSMVRYTPLTFNRWYVYPDWAYALGWLLALSSILL 524

  Fly   550 VSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGP--SDPKKLM 597
            |.|..:||:  |||       ||:||.|          ||.  |...|||
Zfish   525 VPGWALGQM--WAG-------KGTLKQR----------WGHLCSPETKLM 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	183/485 (38%)
si:ch211-132b12.6	NP_001038523.1	SLC6sbd-TauT-like	11..550	CDD:271387	205/563 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920