DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	615	Identity:	208/615 - (33%)
Similarity:	331/615 - (53%)	Gaps:	45/615 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAF 89
            |....:|.:||..||..:.  |...||:.|.:.||||::.....:|||||||||:...:||||||
Zfish     4 SSRPAVKLNLLNGALVKAR--PKPPAREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAF 66

  Fly    90 LIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMAL 153
            .:||::.||..|.|::::|..||||:|:|.:..: ...||..|:|:...:.:.....||..::|.
Zfish    67 FVPYVLFLFTCGIPLFFLETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAW 131

  Fly   154 TLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSRNFSSSTQL-YLQRIVLNETDSLE 216
            ...|.|.||.|||||:.|...|. ..|:..|.....  :.|.|.::|..: :.:|.:|..:..:|
Zfish   132 AFLYLFSSFTSELPWASCNNYWNTPSCMEFSESNIT--EYSPNKTTSPVIEFWERRILGLSGGIE 194

  Fly   217 EGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVM 281
            : ||.....|||.|.::|:.....:.:||||:||..|..|.|||:::.:||||.||||||.:|:.
Zfish   195 Q-IGNVRWDLALCLLLAWIICYFCVWKGVKSTGKVVYFTATFPYLMLIVLLVRGLTLPGAINGIT 258

  Fly   282 YFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLS 346
            ::|.|...:|.:||||.:|.:|:|:|..||.||:....|||::.:|.|||...:..|::.||.::
Zfish   259 FYLYPDPSRLKDPQVWMDAGSQIFYSYGVCTGVLTALGSYNKYDNNCYRDCVYLCLLNSLTSFVA 323

  Fly   347 GVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSN 411
            |..||.:||.:|.|.|. ||:.|.::|||||||:||.|:|...: ||::::.||.|:..||:.|.
Zfish   324 GFAIFSVLGFMADEQGV-DISLVAESGPGLAFIAYPRAVALMPL-PQLWAIFFFIMIIFLGLDSE 386

  Fly   412 VGMVSCIMTVLKDQF-----VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSL 471
            ......::|.:.|.:     |..:...:::.:....|.|||:.:|.||.::..|.|::..:.::|
Zfish   387 FVYQEALVTSISDMYPSFFQVGHRRKFLLLFICSASFFVGLLMVTEGGLYVFQLFDYYACSGMTL 451

  Fly   472 VS-AIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYN 535
            :: ||.:.|.|||:||..|.....|.|:..:...:.:.||..:||.:.....::||:...||.:|
Zfish   452 LTFAILQSICVGWVYGADRHYDCVEDMIGYRPWPFMKCCWKYLTPAICTGTFIFSLVQYTPLKFN 516

  Fly   536 GQ-EFPLVYRVVGWCVSGCIIGQLF---------YWAGYANFKQPKGSLKSRINNSIKPHSDW-G 589
            .: |:|       |.  |..||..|         .|..|.....| ||::.|:.....|..|. .
Zfish   517 NEYEYP-------WW--GYAIGGFFTLSSTLLVPLWMIYLVGTTP-GSMRQRVRALCTPAEDLPD 571

  Fly   590 PSDPKKLMDYQMF--------LRNKDEENS 611
            |..||:.::...|        ||....:||
Zfish   572 PKCPKQKLNTATFETFTDLLTLRTVHIQNS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	171/482 (35%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	190/551 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820