DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and slc6a11a

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001091857.1	Gene:	slc6a11a / 558960	ZFINID:	ZDB-GENE-030131-3729	Length:	590	Species:	Danio rerio

Alignment Length:	600	Identity:	207/600 - (34%)
Similarity:	325/600 - (54%)	Gaps:	46/600 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPI 104
            :.::::|:.  |..|.:.:|||::.....:|||||||||:...:||||||.|||::.|...|.|:
Zfish    12 QQADITPEE--RGQWANKIEFLLTVAGAIIGLGNVWRFPYLCYKNGGGAFFIPYVLYLVTCGIPL 74

  Fly   105 YYMEMLLGQFSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPW 168
            :.:|..|||::|:|.:..: ...||..|:|||..|.:...:..|..::|....|.|.||..||||
Zfish    75 FVLETSLGQYTSQGGIMCWRKVCPLFEGMGYASQLIIVYGSITYIIIIAWAFLYLFSSFNVELPW 139

  Fly   169 SFCREEWG-DGCVSASG-------GQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGS 225
            :.|...|. |.|:..||       ..||      |.|||...:....||..:..:|. :|.....
Zfish   140 ASCNNPWNTDTCIVLSGRNSSSELASPL------NSSSSVMEFWHHRVLRLSSGVEH-LGTVRWD 197

  Fly   226 LALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEK 290
            |||:|.:.|:.|...|.:||||:|||.|..|.||||::.|||:|.:|||||.:|:.|::.|...:
Zfish   198 LALILLLVWILVYFCIWKGVKSTGKAVYFTATFPYVMLLILLLRGVTLPGALNGIYYYMYPDLTR 262

  Fly   291 LLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILG 355
            |.:||||.:|.||:|:|.|:|.|.:....|||::.:|.|||:..:..|::.||.|.|..||.:||
Zfish   263 LADPQVWMDAGTQIFYSYAICLGYLSSLGSYNQYNNNCYRDSFYLCLLNSGTSFLGGFAIFSVLG 327

  Fly   356 NLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFP--QVFSLLFFAMLFMLGVGSN-VGMVSC 417
            ::|.|.|. ||:.|.::||||.||.||.|:.   |.|  |.:::.||.|:.:||:.|. ||:.|
Zfish   328 HMAQEQGV-DISLVAESGPGLVFIVYPQAVT---MLPLSQFWAVCFFIMIILLGLDSQFVGLES- 387

  Fly   418 IMTVLKDQFVNV-----KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFH---GVTFVSLVSA 474
            |||.:.|.|..|     :..::::.:.::.:.:||:.||.||.:||.|.|.:   |.|.:.|  |
Zfish   388 IMTSVTDIFPTVLRRGFRREMLLLGICLVCYFMGLLMITEGGLYIIQLFDHYVCSGTTLLFL--A 450

  Fly   475 IFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQ-E 538
            ..:.:|:||:||..|..::.:.|:..|.....:.||..|||.|.:...::||:...||.:|.: .
Zfish   451 TCQSVAIGWVYGADRFYENIQDMIGYKPWPMVKYCWLYVTPSVCVGTFIFSLVKYSPLKFNNKYM 515

  Fly   539 FPLVYRVVGWCVS----GCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDPKKLMDY 599
            :|.....:||.::    ..|...:.|     ...:.||:...|:..:..|..|...|.......|
Zfish   516 YPWWAYGIGWFLAVSSLSLIPINMIY-----KLHKGKGTFWERLQLACSPAEDLPQSQRPSAHHY 575

  Fly   600 QMFLRNKDEENSKNV 614
            .:......|::..|:
Zfish   576 TLSASTDREKSPDNL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	186/493 (38%)
slc6a11a	NP_001091857.1	SLC6sbd-TauT-like	21..560	CDD:271387	200/557 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820