Protein Alignment CG4476 and SLC6A20

DIOPT Version :9

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001372612.1
• Gene: SLC6A20 / 54716
• HGNCID: 30927
• Length: 603
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 194/635 - (30%)
• Similarity: 310/635 - (48%)
• Gaps: 126/635 - (19%)

  Fly    49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQ 113
            |||..|.:||:|:.:||:.:||||||||||:.....|||:||:||:::|.|.|.|:.|:|:.:||
Human     3 KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67

  Fly   114 FSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGD 177
            ...:|.:..: ..:|.:.|||.|.::....|:.||..:.|....|.|.||...||||.|
Human    68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC------ 126

  Fly   178 GCVSASGGQPLQGQLSR-----NFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALMLGISWLTV 237
                     ||.|..:.     ..:||||.:..|..||.:.||:|. |......||.|.::||.|
Human   127 ---------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQEN-GGVQWEPALCLLLAWLVV 181

  Fly   238 TLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTP-----------QWEKL 291
            .|.|:||.:|:||..|..|..||.|:.|.|:|.|||.||.:|:||..||           |.|:|
Human   182 YLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKGSSALSLLAFQIEQL 246

  Fly   292 LEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILG- 355
            ..|:.|.||.||:||||.:.||.:|.::|||...:|..:.|.||:.:::|||:.:.::.|.|.|
Human   247 ANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF 311

  Fly   356 -------------------------------NL---------AHESGTKDIASVVK--------- 371
                                           ||         |:.|...::...:|
Human   312 KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELD 376

  Fly   372 ---AGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKD-QFVNVKLW 432
               .|.|||||.|.:||...:: .|::|:|:|.||.|||:||.:|..:.|:|.|.| :.::..|.
Human   377 TAVQGTGLAFIVYTEAIKNMEV-SQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLP 440

  Fly   433 IIVVS--LSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAE 495
            ...:|  :.::...:|:::....|.:...:.:.:..|...|:..:.|.|||.::||.:|...|.:
Human   441 KEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLK 505

  Fly   496 YMLNIKTSNYYRICWSIVTPLVMLVILVYSLL------TMRPLSYNGQEFPLVYR--------VV 546
            .|.....|.|:::.|:.|:||:::.:.|:.|.      |::..:::..:..||.:        |:
Human   506 AMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVI 570

  Fly   547 GWCVSG---CIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDP 593
            |..|:.   ||               |..:|.:.:...:|.    |.:||
Human   571 GLLVASSTMCI---------------PLAALGTFVQRRLKR----GDADP 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	176/546 (32%)
SLC6A20	NP_001372612.1	SLC6sbd_SIT1	2..588	CDD:271401	190/616 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810