Protein Alignment CG4476 and Slc6a12

DIOPT Version :10

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_059031.1
• Gene: Slc6a12 / 50676
• RGDID: 620255
• Length: 628
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 203/565 - (35%)
• Similarity: 317/565 - (56%)
• Gaps: 36/565 - (6%)

  Fly    49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQ 113
            |.|..|.:.:||::|.....:|||||||||:...:||||||.|||.:..|..|.|::::|:.|||
  Rat    48 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQ 112

  Fly   114 FSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG- 176
            :||:|.|..: ...||::|:|.|.::....|..||..::|..|.|.|.||..||||:.|...|.
  Rat   113 YSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNT 177

  Fly   177 DGCVS-ASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALMLGISWLTVTLI 240
            :.||. .:.........|.||:|....:.:|.||..|..:.: :|.....|||.|.::|:.....
  Rat   178 EHCVDFLNYSSTRAASYSENFTSPVMEFWERRVLGITSGIHD-LGSLRWELALCLLLAWIICYFC 241

  Fly   241 IIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVF 305
            |.:||||:||..|..|.|||:::.|||:|.:||||||.|::::|.|...:|.:||||.:|.||:|
  Rat   242 IWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIF 306

  Fly   306 FSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVV 370
            ||.|:|.|.:....|||::.:|.|||:..:..|::.||.::|.::|.|||.:|.|.|. .|:.|.
  Rat   307 FSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGV-PISEVA 370

  Fly   371 KAGPGLAFISYPDAIAKFKMFP--QVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV---- 429
            ::|||||||::|.|:.   |.|  |::|.|||.||..||:.|....:.|::|...|.|...
  Rat   371 ESGPGLAFIAFPKAVT---MMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRKR 432

  Fly   430 -KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQ 492
             :..:::::::::.:|:||:.:|.||.:|..|.|::..:.:.|: .::||:|.:||:||..|...
  Rat   433 GRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYD 497

  Fly   493 DAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQ 557
            :.|.|:..:.....:|.|..:||.:.|....:||....||.||.     ||....|   |..||.
  Rat   498 NVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNN-----VYIYPSW---GYSIGW 554

  Fly   558 LFYWAGYA--------NFKQPKGSLKSRINNSIKPHSDWGPSDPK 594
            |..::..|        ...:.:||.|.|:...|.|    .||.|:
  Rat   555 LLAFSSMACVPLFIIITLLKTQGSFKKRLQRLITP----DPSLPQ 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	178/484 (37%)
Slc6a12	NP_059031.1	SLC5-6-like_sbd	49..589	CDD:444915	198/552 (36%)